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Pharmacologic IRE1/XBP1s Activation Confers Targeted ER Proteostasis Reprogramming

Activation of the IRE1/XBP1s signaling arm of the unfolded protein response (UPR) is a promising strategy to correct defects in endoplasmic reticulum (ER) proteostasis implicated in diverse diseases. However, no pharmacologic activators of this pathway identified to date are suitable for ER proteost...

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Detalles Bibliográficos
Autores principales:	Grandjean, Julia M.D., Madhavan, Aparajita, Cech, Lauren, Seguinot, Bryan O., Paxman, Ryan J., Smith, Emery, Scampavia, Louis, Powers, Evan T., Cooley, Christina B., Plate, Lars, Spicer, Timothy P., Kelly, Jeffery W., Wiseman, R. Luke
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7502540/ https://www.ncbi.nlm.nih.gov/pubmed/32690944 http://dx.doi.org/10.1038/s41589-020-0584-z

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