Decreased Colonic Activin Receptor-Like Kinase 1 Disrupts Epithelial Barrier Integrity in Patients With Crohn’s Disease

BACKGROUND & AIMS: Intestinal epithelial cell (IEC) barrier dysfunction is critical to the development of Crohn’s disease (CD). However, the mechanism is understudied. We recently reported increased microRNA-31-5p (miR-31-5p) expression in colonic IECs of CD patients, but downstream targets and...

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Detalles Bibliográficos
Autores principales: Toyonaga, Takahiko, Steinbach, Erin C., Keith, Benjamin P., Barrow, Jasmine B., Schaner, Matthew R., Wolber, Elisabeth A., Beasley, Caroline, Huling, Jennifer, Wang, Yuli, Allbritton, Nancy L., Chaumont, Nicole, Sadiq, Timothy S., Koruda, Mark J., Jain, Animesh, Long, Millie D., Barnes, Edward L., Herfarth, Hans H., Isaacs, Kim L., Hansen, Jonathan J., Shanahan, Michael T., Rahbar, Reza, Furey, Terrence S., Sethupathy, Praveen, Sheikh, Shehzad Z.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7502566/
https://www.ncbi.nlm.nih.gov/pubmed/32561494
http://dx.doi.org/10.1016/j.jcmgh.2020.06.005

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