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Insulin-like Growth Factor-1 and mTORC1 Signaling Promote the Intestinal Regenerative Response After Irradiation Injury

BACKGROUND & AIMS: Intestinal crypts have a remarkable capacity to regenerate after injury from loss of crypt base columnar (CBC) stem cells. After injury, facultative stem cells (FSCs) are activated to replenish the epithelium and replace lost CBCs. Our aim was to assess the role of insulin-lik...

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Detalles Bibliográficos
Autores principales:	Bohin, Natacha, McGowan, Kevin P., Keeley, Theresa M., Carlson, Elizabeth A., Yan, Kelley S., Samuelson, Linda C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2020
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7502577/ https://www.ncbi.nlm.nih.gov/pubmed/32502530 http://dx.doi.org/10.1016/j.jcmgh.2020.05.013

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