Obesity-related hypoxia via miR-128 decreases insulin-receptor expression in human and mouse adipose tissue promoting systemic insulin resistance

BACKGROUND: Insulin resistance in visceral adipose tissue (VAT), skeletal muscle and liver is a prominent feature of most patients with obesity. How this association arises remains poorly understood. The objective of this study was to demonstrate that the decrease in insulin receptor (INSR) expressi...

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Detalles Bibliográficos
Autores principales: Arcidiacono, Biagio, Chiefari, Eusebio, Foryst-Ludwig, Anna, Currò, Giuseppe, Navarra, Giuseppe, Brunetti, Francesco S., Mirabelli, Maria, Corigliano, Domenica M., Kintscher, Ulrich, Britti, Domenico, Mollace, Vincenzo, Foti, Daniela P., Goldfine, Ira D., Brunetti, Antonio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7502675/
https://www.ncbi.nlm.nih.gov/pubmed/32739259
http://dx.doi.org/10.1016/j.ebiom.2020.102912

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7502675/
https://www.ncbi.nlm.nih.gov/pubmed/32739259
http://dx.doi.org/10.1016/j.ebiom.2020.102912

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