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Next-generation gene drive for population modification of the malaria vector mosquito, Anopheles gambiae

A Cas9/guide RNA-based gene drive strain, AgNosCd-1, was developed to deliver antiparasite effector molecules to the malaria vector mosquito, Anopheles gambiae. The drive system targets the cardinal gene ortholog producing a red-eye phenotype. Drive can achieve 98 to 100% in both sexes and full intr...

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Detalles Bibliográficos
Autores principales:	Carballar-Lejarazú, Rebeca, Ogaugwu, Christian, Tushar, Taylor, Kelsey, Adam, Pham, Thai Binh, Murphy, Jazmin, Schmidt, Hanno, Lee, Yoosook, Lanzaro, Gregory C., James, Anthony A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	National Academy of Sciences 2020
Materias:	Biological Sciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7502704/ https://www.ncbi.nlm.nih.gov/pubmed/32839345 http://dx.doi.org/10.1073/pnas.2010214117

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