Characterization and validation of a preventative therapy for hypertrophic cardiomyopathy in a murine model of the disease

Currently there is an unmet need for treatments that can prevent hypertrophic cardiomyopathy (HCM). Using a murine model we previously identified that HCM causing cardiac troponin I mutation Gly203Ser (cTnI-G203S) is associated with increased mitochondrial metabolic activity, consistent with the hum...

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Detalles Bibliográficos
Autores principales: Viola, Helena M., Shah, Ashay A., Johnstone, Victoria P. A., Cserne Szappanos, Henrietta, Hodson, Mark P., Hool, Livia C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2020
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7502707/
https://www.ncbi.nlm.nih.gov/pubmed/32859761
http://dx.doi.org/10.1073/pnas.2002976117

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