Cargando…

Impaired Cytotoxic CD8(+) T Cell Response in Elderly COVID-19 Patients

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection induces a T cell response that most likely contributes to virus control in COVID-19 patients but may also induce immunopathology. Until now, the cytotoxic T cell response has not been very well characterized in COVID-19 patients....

Descripción completa

Detalles Bibliográficos
Autores principales:	Westmeier, Jaana, Paniskaki, Krystallenia, Karaköse, Zehra, Werner, Tanja, Sutter, Kathrin, Dolff, Sebastian, Overbeck, Marvin, Limmer, Andreas, Liu, Jia, Zheng, Xin, Brenner, Thorsten, Berger, Marc M., Witzke, Oliver, Trilling, Mirko, Lu, Mengji, Yang, Dongliang, Babel, Nina, Westhoff, Timm, Dittmer, Ulf, Zelinskyy, Gennadiy
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Microbiology 2020
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7502863/ https://www.ncbi.nlm.nih.gov/pubmed/32948688 http://dx.doi.org/10.1128/mBio.02243-20

Ejemplares similares

Erratum for Westmeier et al., “Impaired Cytotoxic CD8(+) T Cell Response in Elderly COVID-19 Patients”
por: Westmeier, Jaana, et al.
Publicado: (2020)

Macrophage migration inhibitory factor receptor CD74 expression is associated with expansion and differentiation of effector T cells in COVID-19 patients
por: Westmeier, Jaana, et al.
Publicado: (2023)

A Crowned Killer’s Résumé: Genome, Structure, Receptors, and Origin of SARS-CoV-2
por: Wang, Shichuan, et al.
Publicado: (2020)

Severe Acute Respiratory Syndrome Coronavirus 2 Cross-Reactive B and T Cell Responses in Kidney Transplant Patients
por: Paniskaki, Krystallenia, et al.
Publicado: (2022)

SARS-CoV-2-specific T cell responses wane profoundly in convalescent individuals 10 months after primary infection
por: Li, Ziwei, et al.
Publicado: (2023)

Superior humoral immunity in vaccinated SARS-CoV-2 convalescence as compared to SARS-COV-2 infection or vaccination
por: Paniskaki, Krystallenia, et al.
Publicado: (2022)

Generation of potentially inhibitory autoantibodies to ADAMTS13 in coronavirus disease 2019
por: Doevelaar, Adrian A. N., et al.
Publicado: (2023)

Robust T Cell Response Toward Spike, Membrane, and Nucleocapsid SARS-CoV-2 Proteins Is Not Associated with Recovery in Critical COVID-19 Patients
por: Thieme, Constantin J., et al.
Publicado: (2020)

Immune Response in Moderate to Critical Breakthrough COVID-19 Infection After mRNA Vaccination
por: Paniskaki, Krystallenia, et al.
Publicado: (2022)

Low avidity circulating SARS-CoV-2 reactive CD8+ T cells with proinflammatory TEMRA phenotype are associated with post-acute sequelae of COVID-19
por: Paniskaki, Krystallenia, et al.
Publicado: (2023)

Characterization of SARS-CoV-2-Specific Humoral and Cellular Immune Responses Induced by Inactivated COVID-19 Vaccines in a Real-World Setting
por: Li, Ziwei, et al.
Publicado: (2021)

Regulatory T cells suppress the motility of cytotoxic T cells in Friend retrovirus–infected mice
por: Mittermüller, Daniela, et al.
Publicado: (2023)

SARS-CoV-2–reactive cellular and humoral immunity in hemodialysis population
por: Anft, Moritz, et al.
Publicado: (2021)

Fading SARS-CoV-2 humoral VOC cross-reactivity and sustained cellular immunity in convalescent children and adolescents
por: Paniskaki, Krystallenia, et al.
Publicado: (2023)

Impact of low eGFR on the immune response against COVID-19
por: Blazquez-Navarro, Arturo, et al.
Publicado: (2022)

Detection of SARS-CoV-2 pneumonia: two case reports
por: Seibert, Felix S., et al.
Publicado: (2020)

Analysis of the Long-Term Impact on Cellular Immunity in COVID-19-Recovered Individuals Reveals a Profound NKT Cell Impairment
por: Liu, Jia, et al.
Publicado: (2021)

Susceptibility of SARS-CoV-2 to UV irradiation
por: Heilingloh, Christiane Silke, et al.
Publicado: (2020)

Natural regulatory T cells inhibit production of cytotoxic molecules in CD8(+) T cells during low-level Friend retrovirus infection
por: Zelinskyy, Gennadiy, et al.
Publicado: (2013)

Patients with SARS-CoV-2-Induced Viral Sepsis Simultaneously Show Immune Activation, Impaired Immune Function and a Procoagulatory Disease State
por: Limmer, Andreas, et al.
Publicado: (2023)

Friend retrovirus studies reveal complex interactions between intrinsic, innate and adaptive immunity
por: Dittmer, Ulf, et al.
Publicado: (2019)

Reactivations of Latent Viral Infections Are Associated with an Increased Thr389 p70S6k Phosphorylation in Peripheral Lymphocytes of Renal Transplant Recipients
por: Cherneha, Maxim, et al.
Publicado: (2021)

Regulatory T Cells Suppress Antiviral Immune Responses and Increase Viral Loads during Acute Infection with a Lymphotropic Retrovirus
por: Zelinskyy, Gennadiy, et al.
Publicado: (2009)

COVID-19-Induced ARDS Is Associated with Decreased Frequency of Activated Memory/Effector T Cells Expressing CD11a(++)
por: Anft, Moritz, et al.
Publicado: (2020)

SARS-CoV-2 vaccination improves HBV seroconversion rate through heterological immunity
por: Anft, Moritz, et al.
Publicado: (2023)

TLR ligand induced IL-6 counter-regulates the anti-viral CD8(+) T cell response during an acute retrovirus infection
por: Wu, Weimin, et al.
Publicado: (2015)

Fas Ligand-mediated cytotoxicity of CD4+ T cells during chronic retrovirus infection
por: Malyshkina, Anna, et al.
Publicado: (2017)

Different antiviral effects of IFNα subtypes in a mouse model of HBV infection
por: Song, Jingjiao, et al.
Publicado: (2017)

The IL-1R/TLR signaling pathway is essential for efficient CD8(+) T-cell responses against hepatitis B virus in the hydrodynamic injection mouse model
por: Ma, Zhiyong, et al.
Publicado: (2017)

A Vector-Based Vaccine Dose After 3 Doses of mRNA-Based COVID-19 Vaccination Does Not Substantially Improve Humoral SARS-CoV-2 Immunity in Renal Transplant Recipients
por: Roch, Toralf, et al.
Publicado: (2022)

Peripheral HLA-G/ILT-2 immune checkpoint axis in acute and convalescent COVID-19 patients
por: Rohn, Hana, et al.
Publicado: (2023)

Detection of SARS‐CoV‐2‐specific memory B cells to delineate long‐term COVID‐19 immunity
por: Thieme, Constantin J., et al.
Publicado: (2021)

Combining Regulatory T Cell Depletion and Inhibitory Receptor Blockade Improves Reactivation of Exhausted Virus-Specific CD8(+) T Cells and Efficiently Reduces Chronic Retroviral Loads
por: Dietze, Kirsten K., et al.
Publicado: (2013)

Tumor-specific CD4(+) T cells develop cytotoxic activity and eliminate virus-induced tumor cells in the absence of regulatory T cells
por: Akhmetzyanova, Ilseyar, et al.
Publicado: (2012)

Hypoxia-inducible factor 1α is Essential for Macrophage-mediated Erythroblast Proliferation in Acute Friend Retrovirus Infection
por: Schreiber, Timm, et al.
Publicado: (2017)

SARS-CoV-2 Seroprevalence in Healthcare Workers in Germany: A Follow-Up Study
por: Korth, Johannes, et al.
Publicado: (2021)

CD169(+) macrophages regulate PD-L1 expression via type I interferon and thereby prevent severe immunopathology after LCMV infection
por: Shaabani, Namir, et al.
Publicado: (2016)

Granulocytic myeloid-derived suppressor cells suppress virus-specific CD8(+) T cell responses during acute Friend retrovirus infection
por: Drabczyk-Pluta, Malgorzata, et al.
Publicado: (2017)

Superior antiviral activity of IFNβ in genital HSV-1 infection
por: Schmitz, Yasmin, et al.
Publicado: (2022)

Coronavirus Disease 2019 Associated Risk Score, Behavior, and Symptom Prevalence in German Transplant Recipients
por: Thieme, Constantin J., et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_p5l83p6rcgp83npt3fpc12337h