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Response of patients with chest tightness variant asthma with routine asthma treatment regimen: A 1‐year multicenter, prospective, real‐world study

BACKGROUND: Asthmatic patients with chest tightness as their only presenting symptom (chest tightness variant asthma [CTVA]) have clinical characteristics of eosinophilic airway inflammation similar to those of classic asthma (CA); however, whether CTVA has similar response to antiasthma treatment a...

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Autores principales: Yan, Fugui, Li, Wen, Guan, Wei‐jie, Chen, Min, Qiu, Chen, Tang, Wei, Liu, Xiansheng, Xiang, Xudong, Li, Jing, Jin, Meiling, Dai, Yuanrong, Chen, Ping, Wu, Xiaohong, Qiu, Zhongmin, Dong, Liang, Zhao, Limin, Lin, Xiaoping, Wu, Changgui, Wu, Bin, Yuan, Yalian, Shi, Fei, Zhang, Ting, Zhou, Jun, Xie, Min, Fang, Xiaoyu, Zhang, Hongliang, Xiao, Bing, Xian, Mo, Wang, Jian, Qiu, Zhangwei, Lin, Jie, Ji, Bingbing, Zhou, Yong, Li, Yu, Liu, Chunhong, Chen, Yiping, Zeng, Yiming, Liu, Lingli, Hua, Wen, Huang, Huaqiong, Zhou, Jiesen, Hu, Yue, Che, Luanqing, Ying, Songmin, Chen, Zhihua, Zhong, Nanshan, Shen, Huahao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7503098/
https://www.ncbi.nlm.nih.gov/pubmed/32997402
http://dx.doi.org/10.1002/ctm2.178
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author Yan, Fugui
Li, Wen
Guan, Wei‐jie
Chen, Min
Qiu, Chen
Tang, Wei
Liu, Xiansheng
Xiang, Xudong
Li, Jing
Jin, Meiling
Dai, Yuanrong
Chen, Ping
Wu, Xiaohong
Qiu, Zhongmin
Dong, Liang
Zhao, Limin
Lin, Xiaoping
Wu, Changgui
Wu, Bin
Yuan, Yalian
Shi, Fei
Zhang, Ting
Zhou, Jun
Xie, Min
Fang, Xiaoyu
Zhang, Hongliang
Xiao, Bing
Xian, Mo
Wang, Jian
Qiu, Zhangwei
Lin, Jie
Ji, Bingbing
Zhou, Yong
Li, Yu
Liu, Chunhong
Chen, Yiping
Zeng, Yiming
Liu, Lingli
Hua, Wen
Huang, Huaqiong
Zhou, Jiesen
Hu, Yue
Che, Luanqing
Ying, Songmin
Chen, Zhihua
Zhong, Nanshan
Shen, Huahao
author_facet Yan, Fugui
Li, Wen
Guan, Wei‐jie
Chen, Min
Qiu, Chen
Tang, Wei
Liu, Xiansheng
Xiang, Xudong
Li, Jing
Jin, Meiling
Dai, Yuanrong
Chen, Ping
Wu, Xiaohong
Qiu, Zhongmin
Dong, Liang
Zhao, Limin
Lin, Xiaoping
Wu, Changgui
Wu, Bin
Yuan, Yalian
Shi, Fei
Zhang, Ting
Zhou, Jun
Xie, Min
Fang, Xiaoyu
Zhang, Hongliang
Xiao, Bing
Xian, Mo
Wang, Jian
Qiu, Zhangwei
Lin, Jie
Ji, Bingbing
Zhou, Yong
Li, Yu
Liu, Chunhong
Chen, Yiping
Zeng, Yiming
Liu, Lingli
Hua, Wen
Huang, Huaqiong
Zhou, Jiesen
Hu, Yue
Che, Luanqing
Ying, Songmin
Chen, Zhihua
Zhong, Nanshan
Shen, Huahao
author_sort Yan, Fugui
collection PubMed
description BACKGROUND: Asthmatic patients with chest tightness as their only presenting symptom (chest tightness variant asthma [CTVA]) have clinical characteristics of eosinophilic airway inflammation similar to those of classic asthma (CA); however, whether CTVA has similar response to antiasthma treatment as compared with CA remains unclear. OBJECTIVE: The response of 76 CTVA patients to standard asthma treatments with inhaled corticosteroids with long‐acting beta‐agonists was explored in a 52‐week multicenter, prospective, real‐world study. RESULTS: After 52 weeks of treatment with therapy regimens used for CA, the mean 5‐point Asthma Control Questionnaire (ACQ‐5) score decreased markedly from 1.38(first administration) to 0.71 (52 weeks, mean decrease: 0.674, 95%CI: 0.447‐0.900, P<.001).The mean asthma quality‐of‐life questionnaire (AQLQ) score increased from 5.77 (first administration) to 6.20 (52 weeks, mean increase: 0.441, 95% CI 0.258‐0.625, P<.001). Furthermore, at week 52, FVC, FEV(1)%, the diurnal variation in PEFand the PD20‐FEV(1) were significantly improved. Subgroup analysis revealed that the patients at first administration in the responsive group had higher ACQ‐5 scores than those in the nonresponsive group (P < .05). CONCLUSION: In conclusion, patients with CTVA had a good therapeutic response to the guideline‐recommended routine treatment (containing inhaled corticosteroids). The association between the treatment response and the severity of CTVA suggested that CTVA patients with higher ACQ‐5 scores had better therapeutic effects.
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spelling pubmed-75030982020-09-29 Response of patients with chest tightness variant asthma with routine asthma treatment regimen: A 1‐year multicenter, prospective, real‐world study Yan, Fugui Li, Wen Guan, Wei‐jie Chen, Min Qiu, Chen Tang, Wei Liu, Xiansheng Xiang, Xudong Li, Jing Jin, Meiling Dai, Yuanrong Chen, Ping Wu, Xiaohong Qiu, Zhongmin Dong, Liang Zhao, Limin Lin, Xiaoping Wu, Changgui Wu, Bin Yuan, Yalian Shi, Fei Zhang, Ting Zhou, Jun Xie, Min Fang, Xiaoyu Zhang, Hongliang Xiao, Bing Xian, Mo Wang, Jian Qiu, Zhangwei Lin, Jie Ji, Bingbing Zhou, Yong Li, Yu Liu, Chunhong Chen, Yiping Zeng, Yiming Liu, Lingli Hua, Wen Huang, Huaqiong Zhou, Jiesen Hu, Yue Che, Luanqing Ying, Songmin Chen, Zhihua Zhong, Nanshan Shen, Huahao Clin Transl Med Letter to Editor BACKGROUND: Asthmatic patients with chest tightness as their only presenting symptom (chest tightness variant asthma [CTVA]) have clinical characteristics of eosinophilic airway inflammation similar to those of classic asthma (CA); however, whether CTVA has similar response to antiasthma treatment as compared with CA remains unclear. OBJECTIVE: The response of 76 CTVA patients to standard asthma treatments with inhaled corticosteroids with long‐acting beta‐agonists was explored in a 52‐week multicenter, prospective, real‐world study. RESULTS: After 52 weeks of treatment with therapy regimens used for CA, the mean 5‐point Asthma Control Questionnaire (ACQ‐5) score decreased markedly from 1.38(first administration) to 0.71 (52 weeks, mean decrease: 0.674, 95%CI: 0.447‐0.900, P<.001).The mean asthma quality‐of‐life questionnaire (AQLQ) score increased from 5.77 (first administration) to 6.20 (52 weeks, mean increase: 0.441, 95% CI 0.258‐0.625, P<.001). Furthermore, at week 52, FVC, FEV(1)%, the diurnal variation in PEFand the PD20‐FEV(1) were significantly improved. Subgroup analysis revealed that the patients at first administration in the responsive group had higher ACQ‐5 scores than those in the nonresponsive group (P < .05). CONCLUSION: In conclusion, patients with CTVA had a good therapeutic response to the guideline‐recommended routine treatment (containing inhaled corticosteroids). The association between the treatment response and the severity of CTVA suggested that CTVA patients with higher ACQ‐5 scores had better therapeutic effects. John Wiley and Sons Inc. 2020-09-15 /pmc/articles/PMC7503098/ /pubmed/32997402 http://dx.doi.org/10.1002/ctm2.178 Text en © 2020 The Authors. Clinical and Translational Medicine published by John Wiley & Sons Australia, Ltd on behalf of Shanghai Institute of Clinical Bioinformatics This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Letter to Editor
Yan, Fugui
Li, Wen
Guan, Wei‐jie
Chen, Min
Qiu, Chen
Tang, Wei
Liu, Xiansheng
Xiang, Xudong
Li, Jing
Jin, Meiling
Dai, Yuanrong
Chen, Ping
Wu, Xiaohong
Qiu, Zhongmin
Dong, Liang
Zhao, Limin
Lin, Xiaoping
Wu, Changgui
Wu, Bin
Yuan, Yalian
Shi, Fei
Zhang, Ting
Zhou, Jun
Xie, Min
Fang, Xiaoyu
Zhang, Hongliang
Xiao, Bing
Xian, Mo
Wang, Jian
Qiu, Zhangwei
Lin, Jie
Ji, Bingbing
Zhou, Yong
Li, Yu
Liu, Chunhong
Chen, Yiping
Zeng, Yiming
Liu, Lingli
Hua, Wen
Huang, Huaqiong
Zhou, Jiesen
Hu, Yue
Che, Luanqing
Ying, Songmin
Chen, Zhihua
Zhong, Nanshan
Shen, Huahao
Response of patients with chest tightness variant asthma with routine asthma treatment regimen: A 1‐year multicenter, prospective, real‐world study
title Response of patients with chest tightness variant asthma with routine asthma treatment regimen: A 1‐year multicenter, prospective, real‐world study
title_full Response of patients with chest tightness variant asthma with routine asthma treatment regimen: A 1‐year multicenter, prospective, real‐world study
title_fullStr Response of patients with chest tightness variant asthma with routine asthma treatment regimen: A 1‐year multicenter, prospective, real‐world study
title_full_unstemmed Response of patients with chest tightness variant asthma with routine asthma treatment regimen: A 1‐year multicenter, prospective, real‐world study
title_short Response of patients with chest tightness variant asthma with routine asthma treatment regimen: A 1‐year multicenter, prospective, real‐world study
title_sort response of patients with chest tightness variant asthma with routine asthma treatment regimen: a 1‐year multicenter, prospective, real‐world study
topic Letter to Editor
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7503098/
https://www.ncbi.nlm.nih.gov/pubmed/32997402
http://dx.doi.org/10.1002/ctm2.178
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