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Response of patients with chest tightness variant asthma with routine asthma treatment regimen: A 1‐year multicenter, prospective, real‐world study
BACKGROUND: Asthmatic patients with chest tightness as their only presenting symptom (chest tightness variant asthma [CTVA]) have clinical characteristics of eosinophilic airway inflammation similar to those of classic asthma (CA); however, whether CTVA has similar response to antiasthma treatment a...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7503098/ https://www.ncbi.nlm.nih.gov/pubmed/32997402 http://dx.doi.org/10.1002/ctm2.178 |
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author | Yan, Fugui Li, Wen Guan, Wei‐jie Chen, Min Qiu, Chen Tang, Wei Liu, Xiansheng Xiang, Xudong Li, Jing Jin, Meiling Dai, Yuanrong Chen, Ping Wu, Xiaohong Qiu, Zhongmin Dong, Liang Zhao, Limin Lin, Xiaoping Wu, Changgui Wu, Bin Yuan, Yalian Shi, Fei Zhang, Ting Zhou, Jun Xie, Min Fang, Xiaoyu Zhang, Hongliang Xiao, Bing Xian, Mo Wang, Jian Qiu, Zhangwei Lin, Jie Ji, Bingbing Zhou, Yong Li, Yu Liu, Chunhong Chen, Yiping Zeng, Yiming Liu, Lingli Hua, Wen Huang, Huaqiong Zhou, Jiesen Hu, Yue Che, Luanqing Ying, Songmin Chen, Zhihua Zhong, Nanshan Shen, Huahao |
author_facet | Yan, Fugui Li, Wen Guan, Wei‐jie Chen, Min Qiu, Chen Tang, Wei Liu, Xiansheng Xiang, Xudong Li, Jing Jin, Meiling Dai, Yuanrong Chen, Ping Wu, Xiaohong Qiu, Zhongmin Dong, Liang Zhao, Limin Lin, Xiaoping Wu, Changgui Wu, Bin Yuan, Yalian Shi, Fei Zhang, Ting Zhou, Jun Xie, Min Fang, Xiaoyu Zhang, Hongliang Xiao, Bing Xian, Mo Wang, Jian Qiu, Zhangwei Lin, Jie Ji, Bingbing Zhou, Yong Li, Yu Liu, Chunhong Chen, Yiping Zeng, Yiming Liu, Lingli Hua, Wen Huang, Huaqiong Zhou, Jiesen Hu, Yue Che, Luanqing Ying, Songmin Chen, Zhihua Zhong, Nanshan Shen, Huahao |
author_sort | Yan, Fugui |
collection | PubMed |
description | BACKGROUND: Asthmatic patients with chest tightness as their only presenting symptom (chest tightness variant asthma [CTVA]) have clinical characteristics of eosinophilic airway inflammation similar to those of classic asthma (CA); however, whether CTVA has similar response to antiasthma treatment as compared with CA remains unclear. OBJECTIVE: The response of 76 CTVA patients to standard asthma treatments with inhaled corticosteroids with long‐acting beta‐agonists was explored in a 52‐week multicenter, prospective, real‐world study. RESULTS: After 52 weeks of treatment with therapy regimens used for CA, the mean 5‐point Asthma Control Questionnaire (ACQ‐5) score decreased markedly from 1.38(first administration) to 0.71 (52 weeks, mean decrease: 0.674, 95%CI: 0.447‐0.900, P<.001).The mean asthma quality‐of‐life questionnaire (AQLQ) score increased from 5.77 (first administration) to 6.20 (52 weeks, mean increase: 0.441, 95% CI 0.258‐0.625, P<.001). Furthermore, at week 52, FVC, FEV(1)%, the diurnal variation in PEFand the PD20‐FEV(1) were significantly improved. Subgroup analysis revealed that the patients at first administration in the responsive group had higher ACQ‐5 scores than those in the nonresponsive group (P < .05). CONCLUSION: In conclusion, patients with CTVA had a good therapeutic response to the guideline‐recommended routine treatment (containing inhaled corticosteroids). The association between the treatment response and the severity of CTVA suggested that CTVA patients with higher ACQ‐5 scores had better therapeutic effects. |
format | Online Article Text |
id | pubmed-7503098 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-75030982020-09-29 Response of patients with chest tightness variant asthma with routine asthma treatment regimen: A 1‐year multicenter, prospective, real‐world study Yan, Fugui Li, Wen Guan, Wei‐jie Chen, Min Qiu, Chen Tang, Wei Liu, Xiansheng Xiang, Xudong Li, Jing Jin, Meiling Dai, Yuanrong Chen, Ping Wu, Xiaohong Qiu, Zhongmin Dong, Liang Zhao, Limin Lin, Xiaoping Wu, Changgui Wu, Bin Yuan, Yalian Shi, Fei Zhang, Ting Zhou, Jun Xie, Min Fang, Xiaoyu Zhang, Hongliang Xiao, Bing Xian, Mo Wang, Jian Qiu, Zhangwei Lin, Jie Ji, Bingbing Zhou, Yong Li, Yu Liu, Chunhong Chen, Yiping Zeng, Yiming Liu, Lingli Hua, Wen Huang, Huaqiong Zhou, Jiesen Hu, Yue Che, Luanqing Ying, Songmin Chen, Zhihua Zhong, Nanshan Shen, Huahao Clin Transl Med Letter to Editor BACKGROUND: Asthmatic patients with chest tightness as their only presenting symptom (chest tightness variant asthma [CTVA]) have clinical characteristics of eosinophilic airway inflammation similar to those of classic asthma (CA); however, whether CTVA has similar response to antiasthma treatment as compared with CA remains unclear. OBJECTIVE: The response of 76 CTVA patients to standard asthma treatments with inhaled corticosteroids with long‐acting beta‐agonists was explored in a 52‐week multicenter, prospective, real‐world study. RESULTS: After 52 weeks of treatment with therapy regimens used for CA, the mean 5‐point Asthma Control Questionnaire (ACQ‐5) score decreased markedly from 1.38(first administration) to 0.71 (52 weeks, mean decrease: 0.674, 95%CI: 0.447‐0.900, P<.001).The mean asthma quality‐of‐life questionnaire (AQLQ) score increased from 5.77 (first administration) to 6.20 (52 weeks, mean increase: 0.441, 95% CI 0.258‐0.625, P<.001). Furthermore, at week 52, FVC, FEV(1)%, the diurnal variation in PEFand the PD20‐FEV(1) were significantly improved. Subgroup analysis revealed that the patients at first administration in the responsive group had higher ACQ‐5 scores than those in the nonresponsive group (P < .05). CONCLUSION: In conclusion, patients with CTVA had a good therapeutic response to the guideline‐recommended routine treatment (containing inhaled corticosteroids). The association between the treatment response and the severity of CTVA suggested that CTVA patients with higher ACQ‐5 scores had better therapeutic effects. John Wiley and Sons Inc. 2020-09-15 /pmc/articles/PMC7503098/ /pubmed/32997402 http://dx.doi.org/10.1002/ctm2.178 Text en © 2020 The Authors. Clinical and Translational Medicine published by John Wiley & Sons Australia, Ltd on behalf of Shanghai Institute of Clinical Bioinformatics This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Letter to Editor Yan, Fugui Li, Wen Guan, Wei‐jie Chen, Min Qiu, Chen Tang, Wei Liu, Xiansheng Xiang, Xudong Li, Jing Jin, Meiling Dai, Yuanrong Chen, Ping Wu, Xiaohong Qiu, Zhongmin Dong, Liang Zhao, Limin Lin, Xiaoping Wu, Changgui Wu, Bin Yuan, Yalian Shi, Fei Zhang, Ting Zhou, Jun Xie, Min Fang, Xiaoyu Zhang, Hongliang Xiao, Bing Xian, Mo Wang, Jian Qiu, Zhangwei Lin, Jie Ji, Bingbing Zhou, Yong Li, Yu Liu, Chunhong Chen, Yiping Zeng, Yiming Liu, Lingli Hua, Wen Huang, Huaqiong Zhou, Jiesen Hu, Yue Che, Luanqing Ying, Songmin Chen, Zhihua Zhong, Nanshan Shen, Huahao Response of patients with chest tightness variant asthma with routine asthma treatment regimen: A 1‐year multicenter, prospective, real‐world study |
title | Response of patients with chest tightness variant asthma with routine asthma treatment regimen: A 1‐year multicenter, prospective, real‐world study |
title_full | Response of patients with chest tightness variant asthma with routine asthma treatment regimen: A 1‐year multicenter, prospective, real‐world study |
title_fullStr | Response of patients with chest tightness variant asthma with routine asthma treatment regimen: A 1‐year multicenter, prospective, real‐world study |
title_full_unstemmed | Response of patients with chest tightness variant asthma with routine asthma treatment regimen: A 1‐year multicenter, prospective, real‐world study |
title_short | Response of patients with chest tightness variant asthma with routine asthma treatment regimen: A 1‐year multicenter, prospective, real‐world study |
title_sort | response of patients with chest tightness variant asthma with routine asthma treatment regimen: a 1‐year multicenter, prospective, real‐world study |
topic | Letter to Editor |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7503098/ https://www.ncbi.nlm.nih.gov/pubmed/32997402 http://dx.doi.org/10.1002/ctm2.178 |
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