RNF43 truncations trap CK1 to drive niche‐independent self‐renewal in cancer

Wnt/β‐catenin signaling is a primary pathway for stem cell maintenance during tissue renewal and a frequent target for mutations in cancer. Impaired Wnt receptor endocytosis due to loss of the ubiquitin ligase RNF43 gives rise to Wnt‐hypersensitive tumors that are susceptible to anti‐Wnt‐based thera...

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Detalles Bibliográficos
Autores principales: Spit, Maureen, Fenderico, Nicola, Jordens, Ingrid, Radaszkiewicz, Tomasz, Lindeboom, Rik GH, Bugter, Jeroen M, Cristobal, Alba, Ootes, Lars, van Osch, Max, Janssen, Eline, Boonekamp, Kim E, Hanakova, Katerina, Potesil, David, Zdrahal, Zbynek, Boj, Sylvia F, Medema, Jan Paul, Bryja, Vitezslav, Koo, Bon‐Kyoung, Vermeulen, Michiel, Maurice, Madelon M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7503102/
https://www.ncbi.nlm.nih.gov/pubmed/32965059
http://dx.doi.org/10.15252/embj.2019103932

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7503102/
https://www.ncbi.nlm.nih.gov/pubmed/32965059
http://dx.doi.org/10.15252/embj.2019103932

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