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Integrating Gene and Protein Expression Reveals Perturbed Functional Networks in Alzheimer’s Disease

Asymptomatic and symptomatic Alzheimer’s disease (AD) subjects may present with equivalent neuropathological burdens but have significantly different antemortem cognitive decline rates. Using the transcriptome as a proxy for functional state, we selected 414 expression profiles of symptomatic AD sub...

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Detalles Bibliográficos
Autores principales: Canchi, Saranya, Raao, Balaji, Masliah, Deborah, Rosenthal, Sara Brin, Sasik, Roman, Fisch, Kathleen M., De Jager, Philip L., Bennett, David A., Rissman, Robert A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7503200/
https://www.ncbi.nlm.nih.gov/pubmed/31340147
http://dx.doi.org/10.1016/j.celrep.2019.06.073