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There and Back Again: Leptin Actions in White Adipose Tissue

Leptin is a hormone discovered almost 30 years ago with important implications in metabolism. It is primarily produced by white adipose tissue (WAT) in proportion to the amount of fat. The discovery of leptin was a turning point for two principle reasons: on one hand, it generated promising expectat...

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Autor principal: Martínez-Sánchez, Noelia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7503240/
https://www.ncbi.nlm.nih.gov/pubmed/32839413
http://dx.doi.org/10.3390/ijms21176039
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author Martínez-Sánchez, Noelia
author_facet Martínez-Sánchez, Noelia
author_sort Martínez-Sánchez, Noelia
collection PubMed
description Leptin is a hormone discovered almost 30 years ago with important implications in metabolism. It is primarily produced by white adipose tissue (WAT) in proportion to the amount of fat. The discovery of leptin was a turning point for two principle reasons: on one hand, it generated promising expectations for the treatment of the obesity, and on the other, it changed the classical concept that white adipose tissue was simply an inert storage organ. Thus, adipocytes in WAT produce the majority of leptin and, although its primary role is the regulation of fat stores by controlling lipolysis and lipogenesis, this hormone also has implications in other physiological processes within WAT, such as apoptosis, browning and inflammation. Although a massive number of questions related to leptin actions have been answered, the necessity for further clarification facilitates constantly renewing interest in this hormone and its pathways. In this review, leptin actions in white adipose tissue will be summarized in the context of obesity.
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spelling pubmed-75032402020-09-23 There and Back Again: Leptin Actions in White Adipose Tissue Martínez-Sánchez, Noelia Int J Mol Sci Review Leptin is a hormone discovered almost 30 years ago with important implications in metabolism. It is primarily produced by white adipose tissue (WAT) in proportion to the amount of fat. The discovery of leptin was a turning point for two principle reasons: on one hand, it generated promising expectations for the treatment of the obesity, and on the other, it changed the classical concept that white adipose tissue was simply an inert storage organ. Thus, adipocytes in WAT produce the majority of leptin and, although its primary role is the regulation of fat stores by controlling lipolysis and lipogenesis, this hormone also has implications in other physiological processes within WAT, such as apoptosis, browning and inflammation. Although a massive number of questions related to leptin actions have been answered, the necessity for further clarification facilitates constantly renewing interest in this hormone and its pathways. In this review, leptin actions in white adipose tissue will be summarized in the context of obesity. MDPI 2020-08-21 /pmc/articles/PMC7503240/ /pubmed/32839413 http://dx.doi.org/10.3390/ijms21176039 Text en © 2020 by the author. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Martínez-Sánchez, Noelia
There and Back Again: Leptin Actions in White Adipose Tissue
title There and Back Again: Leptin Actions in White Adipose Tissue
title_full There and Back Again: Leptin Actions in White Adipose Tissue
title_fullStr There and Back Again: Leptin Actions in White Adipose Tissue
title_full_unstemmed There and Back Again: Leptin Actions in White Adipose Tissue
title_short There and Back Again: Leptin Actions in White Adipose Tissue
title_sort there and back again: leptin actions in white adipose tissue
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7503240/
https://www.ncbi.nlm.nih.gov/pubmed/32839413
http://dx.doi.org/10.3390/ijms21176039
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