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Antipsychotic Drugs in Prevention of Postoperative Delirium—What Is Known in 2020?

Delirium is one of the most frequently reported neuropsychiatric complications in the perioperative period, especially in the population of elderly patients who often suffer from numerous comorbidities undergoing extensive or urgent surgery. It can affect up to 80% of patients who require hospitaliz...

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Autores principales: Pluta, Michał P., Dziech, Magdalena, Czempik, Piotr F., Szczepańska, Anna J., Krzych, Łukasz J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7503241/
https://www.ncbi.nlm.nih.gov/pubmed/32825428
http://dx.doi.org/10.3390/ijerph17176069
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author Pluta, Michał P.
Dziech, Magdalena
Czempik, Piotr F.
Szczepańska, Anna J.
Krzych, Łukasz J.
author_facet Pluta, Michał P.
Dziech, Magdalena
Czempik, Piotr F.
Szczepańska, Anna J.
Krzych, Łukasz J.
author_sort Pluta, Michał P.
collection PubMed
description Delirium is one of the most frequently reported neuropsychiatric complications in the perioperative period, especially in the population of elderly patients who often suffer from numerous comorbidities undergoing extensive or urgent surgery. It can affect up to 80% of patients who require hospitalization in an intensive care setting postoperatively. Delirium increases mortality, morbidity, length of hospital stay, and cost of treatment. An episode of delirium in the acute phase may lower the general quality of life and increases the risk of cognitive decline long-term. Since pharmacological treatment of delirium is not highly effective, focus of research has shifted towards developing preventive strategies. We aimed to perform a review of the topic based on the most recent literature. We conclude that, based on the available data, it seems impossible to make strong recommendations for using antipsychotic drugs in prophylaxis. Further research should answer the question what, if any, benefit patients receive from the pharmacological prevention of delirium, and which agents should be used.
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spelling pubmed-75032412020-09-23 Antipsychotic Drugs in Prevention of Postoperative Delirium—What Is Known in 2020? Pluta, Michał P. Dziech, Magdalena Czempik, Piotr F. Szczepańska, Anna J. Krzych, Łukasz J. Int J Environ Res Public Health Review Delirium is one of the most frequently reported neuropsychiatric complications in the perioperative period, especially in the population of elderly patients who often suffer from numerous comorbidities undergoing extensive or urgent surgery. It can affect up to 80% of patients who require hospitalization in an intensive care setting postoperatively. Delirium increases mortality, morbidity, length of hospital stay, and cost of treatment. An episode of delirium in the acute phase may lower the general quality of life and increases the risk of cognitive decline long-term. Since pharmacological treatment of delirium is not highly effective, focus of research has shifted towards developing preventive strategies. We aimed to perform a review of the topic based on the most recent literature. We conclude that, based on the available data, it seems impossible to make strong recommendations for using antipsychotic drugs in prophylaxis. Further research should answer the question what, if any, benefit patients receive from the pharmacological prevention of delirium, and which agents should be used. MDPI 2020-08-20 2020-09 /pmc/articles/PMC7503241/ /pubmed/32825428 http://dx.doi.org/10.3390/ijerph17176069 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Pluta, Michał P.
Dziech, Magdalena
Czempik, Piotr F.
Szczepańska, Anna J.
Krzych, Łukasz J.
Antipsychotic Drugs in Prevention of Postoperative Delirium—What Is Known in 2020?
title Antipsychotic Drugs in Prevention of Postoperative Delirium—What Is Known in 2020?
title_full Antipsychotic Drugs in Prevention of Postoperative Delirium—What Is Known in 2020?
title_fullStr Antipsychotic Drugs in Prevention of Postoperative Delirium—What Is Known in 2020?
title_full_unstemmed Antipsychotic Drugs in Prevention of Postoperative Delirium—What Is Known in 2020?
title_short Antipsychotic Drugs in Prevention of Postoperative Delirium—What Is Known in 2020?
title_sort antipsychotic drugs in prevention of postoperative delirium—what is known in 2020?
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7503241/
https://www.ncbi.nlm.nih.gov/pubmed/32825428
http://dx.doi.org/10.3390/ijerph17176069
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