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Downregulation of TAP1 in Tumor-Free Tongue Contralateral to Squamous Cell Carcinoma of the Oral Tongue, an Indicator of Better Survival

Oral cancers are surrounded by epithelium that histologically might seem normal, but genetically has aberrations. In patients with squamous cell carcinoma of the oral tongue (SCCOT), it is therefore important to study not only the tumor but also the clinically tumor-free contralateral tongue tissue...

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Autores principales: Attaran, Nima, Gu, Xiaolian, Coates, Philip J., Fåhraeus, Robin, Boldrup, Linda, Wilms, Torben, Wang, Lixiao, Sgaramella, Nicola, Zborayova, Katarina, Nylander, Karin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7503265/
https://www.ncbi.nlm.nih.gov/pubmed/32867395
http://dx.doi.org/10.3390/ijms21176220
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author Attaran, Nima
Gu, Xiaolian
Coates, Philip J.
Fåhraeus, Robin
Boldrup, Linda
Wilms, Torben
Wang, Lixiao
Sgaramella, Nicola
Zborayova, Katarina
Nylander, Karin
author_facet Attaran, Nima
Gu, Xiaolian
Coates, Philip J.
Fåhraeus, Robin
Boldrup, Linda
Wilms, Torben
Wang, Lixiao
Sgaramella, Nicola
Zborayova, Katarina
Nylander, Karin
author_sort Attaran, Nima
collection PubMed
description Oral cancers are surrounded by epithelium that histologically might seem normal, but genetically has aberrations. In patients with squamous cell carcinoma of the oral tongue (SCCOT), it is therefore important to study not only the tumor but also the clinically tumor-free contralateral tongue tissue that remains in the patient after treatment to map changes of prognostic and/or diagnostic value. The transporter associated with antigen processing (TAP) dimer is a key factor in the process of activating cytotoxic T cells. By downregulating the expression of TAP, tumor cells can escape cytotoxic T cell recognition. Biopsies from tumor and clinically tumor-free contralateral tongue tissue in 21 patients with SCCOT were analyzed together with tongue biopsies from 14 healthy individuals, which served as the control group. Dividing patients into TAP1-high and TAP1-low groups according to the median TAP1 level in tumor-free samples showed that patients with lower TAP1 mRNA levels in tumor-free samples had better overall (p = 0.003) and disease-free survival (p = 0.002). The results showing that TAP1 levels in tumor-free tongue tissue contralateral to the SCCOT correlate with survival is an important contribution to early diagnosis and follow up of SCCOT.
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spelling pubmed-75032652020-09-23 Downregulation of TAP1 in Tumor-Free Tongue Contralateral to Squamous Cell Carcinoma of the Oral Tongue, an Indicator of Better Survival Attaran, Nima Gu, Xiaolian Coates, Philip J. Fåhraeus, Robin Boldrup, Linda Wilms, Torben Wang, Lixiao Sgaramella, Nicola Zborayova, Katarina Nylander, Karin Int J Mol Sci Article Oral cancers are surrounded by epithelium that histologically might seem normal, but genetically has aberrations. In patients with squamous cell carcinoma of the oral tongue (SCCOT), it is therefore important to study not only the tumor but also the clinically tumor-free contralateral tongue tissue that remains in the patient after treatment to map changes of prognostic and/or diagnostic value. The transporter associated with antigen processing (TAP) dimer is a key factor in the process of activating cytotoxic T cells. By downregulating the expression of TAP, tumor cells can escape cytotoxic T cell recognition. Biopsies from tumor and clinically tumor-free contralateral tongue tissue in 21 patients with SCCOT were analyzed together with tongue biopsies from 14 healthy individuals, which served as the control group. Dividing patients into TAP1-high and TAP1-low groups according to the median TAP1 level in tumor-free samples showed that patients with lower TAP1 mRNA levels in tumor-free samples had better overall (p = 0.003) and disease-free survival (p = 0.002). The results showing that TAP1 levels in tumor-free tongue tissue contralateral to the SCCOT correlate with survival is an important contribution to early diagnosis and follow up of SCCOT. MDPI 2020-08-27 /pmc/articles/PMC7503265/ /pubmed/32867395 http://dx.doi.org/10.3390/ijms21176220 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Attaran, Nima
Gu, Xiaolian
Coates, Philip J.
Fåhraeus, Robin
Boldrup, Linda
Wilms, Torben
Wang, Lixiao
Sgaramella, Nicola
Zborayova, Katarina
Nylander, Karin
Downregulation of TAP1 in Tumor-Free Tongue Contralateral to Squamous Cell Carcinoma of the Oral Tongue, an Indicator of Better Survival
title Downregulation of TAP1 in Tumor-Free Tongue Contralateral to Squamous Cell Carcinoma of the Oral Tongue, an Indicator of Better Survival
title_full Downregulation of TAP1 in Tumor-Free Tongue Contralateral to Squamous Cell Carcinoma of the Oral Tongue, an Indicator of Better Survival
title_fullStr Downregulation of TAP1 in Tumor-Free Tongue Contralateral to Squamous Cell Carcinoma of the Oral Tongue, an Indicator of Better Survival
title_full_unstemmed Downregulation of TAP1 in Tumor-Free Tongue Contralateral to Squamous Cell Carcinoma of the Oral Tongue, an Indicator of Better Survival
title_short Downregulation of TAP1 in Tumor-Free Tongue Contralateral to Squamous Cell Carcinoma of the Oral Tongue, an Indicator of Better Survival
title_sort downregulation of tap1 in tumor-free tongue contralateral to squamous cell carcinoma of the oral tongue, an indicator of better survival
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7503265/
https://www.ncbi.nlm.nih.gov/pubmed/32867395
http://dx.doi.org/10.3390/ijms21176220
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