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The Role of MicroRNAs in Bone Metabolism and Disease

Bone metabolism is an intricate process involving various bone cells, signaling pathways, cytokines, hormones, growth factors, etc., and the slightest deviation can result in various bone disorders including osteoporosis, arthropathy, and avascular necrosis of femoral head. Osteoporosis is one of th...

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Detalles Bibliográficos
Autores principales: Gao, Yongguang, Patil, Suryaji, Qian, Airong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7503277/
https://www.ncbi.nlm.nih.gov/pubmed/32846921
http://dx.doi.org/10.3390/ijms21176081
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author Gao, Yongguang
Patil, Suryaji
Qian, Airong
author_facet Gao, Yongguang
Patil, Suryaji
Qian, Airong
author_sort Gao, Yongguang
collection PubMed
description Bone metabolism is an intricate process involving various bone cells, signaling pathways, cytokines, hormones, growth factors, etc., and the slightest deviation can result in various bone disorders including osteoporosis, arthropathy, and avascular necrosis of femoral head. Osteoporosis is one of the most prevalent disorders affecting the skeleton, which is characterized by low bone mass and bone mineral density caused by the disruption in the balanced process of bone formation and bone resorption. The current pharmaceutical treatments such as bisphosphonates, selective estrogen receptor modulator, calcitonin, teriparatide, etc., could decrease the risk of fractures but have side-effects that have limited their long term applications. MicroRNAs (miRNAs) are one of many non-coding RNAs. These are single-stranded with a length of 19–25 nucleotides and can influence various cellular processes and play an important role in various diseases. Therefore, in this article, we review the different functions of different miRNA in bone metabolism and osteoporosis to understand their mechanism of action for the development of possible therapeutics.
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spelling pubmed-75032772020-09-23 The Role of MicroRNAs in Bone Metabolism and Disease Gao, Yongguang Patil, Suryaji Qian, Airong Int J Mol Sci Review Bone metabolism is an intricate process involving various bone cells, signaling pathways, cytokines, hormones, growth factors, etc., and the slightest deviation can result in various bone disorders including osteoporosis, arthropathy, and avascular necrosis of femoral head. Osteoporosis is one of the most prevalent disorders affecting the skeleton, which is characterized by low bone mass and bone mineral density caused by the disruption in the balanced process of bone formation and bone resorption. The current pharmaceutical treatments such as bisphosphonates, selective estrogen receptor modulator, calcitonin, teriparatide, etc., could decrease the risk of fractures but have side-effects that have limited their long term applications. MicroRNAs (miRNAs) are one of many non-coding RNAs. These are single-stranded with a length of 19–25 nucleotides and can influence various cellular processes and play an important role in various diseases. Therefore, in this article, we review the different functions of different miRNA in bone metabolism and osteoporosis to understand their mechanism of action for the development of possible therapeutics. MDPI 2020-08-24 /pmc/articles/PMC7503277/ /pubmed/32846921 http://dx.doi.org/10.3390/ijms21176081 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Gao, Yongguang
Patil, Suryaji
Qian, Airong
The Role of MicroRNAs in Bone Metabolism and Disease
title The Role of MicroRNAs in Bone Metabolism and Disease
title_full The Role of MicroRNAs in Bone Metabolism and Disease
title_fullStr The Role of MicroRNAs in Bone Metabolism and Disease
title_full_unstemmed The Role of MicroRNAs in Bone Metabolism and Disease
title_short The Role of MicroRNAs in Bone Metabolism and Disease
title_sort role of micrornas in bone metabolism and disease
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7503277/
https://www.ncbi.nlm.nih.gov/pubmed/32846921
http://dx.doi.org/10.3390/ijms21176081
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