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The Role of MicroRNAs in Bone Metabolism and Disease
Bone metabolism is an intricate process involving various bone cells, signaling pathways, cytokines, hormones, growth factors, etc., and the slightest deviation can result in various bone disorders including osteoporosis, arthropathy, and avascular necrosis of femoral head. Osteoporosis is one of th...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7503277/ https://www.ncbi.nlm.nih.gov/pubmed/32846921 http://dx.doi.org/10.3390/ijms21176081 |
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author | Gao, Yongguang Patil, Suryaji Qian, Airong |
author_facet | Gao, Yongguang Patil, Suryaji Qian, Airong |
author_sort | Gao, Yongguang |
collection | PubMed |
description | Bone metabolism is an intricate process involving various bone cells, signaling pathways, cytokines, hormones, growth factors, etc., and the slightest deviation can result in various bone disorders including osteoporosis, arthropathy, and avascular necrosis of femoral head. Osteoporosis is one of the most prevalent disorders affecting the skeleton, which is characterized by low bone mass and bone mineral density caused by the disruption in the balanced process of bone formation and bone resorption. The current pharmaceutical treatments such as bisphosphonates, selective estrogen receptor modulator, calcitonin, teriparatide, etc., could decrease the risk of fractures but have side-effects that have limited their long term applications. MicroRNAs (miRNAs) are one of many non-coding RNAs. These are single-stranded with a length of 19–25 nucleotides and can influence various cellular processes and play an important role in various diseases. Therefore, in this article, we review the different functions of different miRNA in bone metabolism and osteoporosis to understand their mechanism of action for the development of possible therapeutics. |
format | Online Article Text |
id | pubmed-7503277 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-75032772020-09-23 The Role of MicroRNAs in Bone Metabolism and Disease Gao, Yongguang Patil, Suryaji Qian, Airong Int J Mol Sci Review Bone metabolism is an intricate process involving various bone cells, signaling pathways, cytokines, hormones, growth factors, etc., and the slightest deviation can result in various bone disorders including osteoporosis, arthropathy, and avascular necrosis of femoral head. Osteoporosis is one of the most prevalent disorders affecting the skeleton, which is characterized by low bone mass and bone mineral density caused by the disruption in the balanced process of bone formation and bone resorption. The current pharmaceutical treatments such as bisphosphonates, selective estrogen receptor modulator, calcitonin, teriparatide, etc., could decrease the risk of fractures but have side-effects that have limited their long term applications. MicroRNAs (miRNAs) are one of many non-coding RNAs. These are single-stranded with a length of 19–25 nucleotides and can influence various cellular processes and play an important role in various diseases. Therefore, in this article, we review the different functions of different miRNA in bone metabolism and osteoporosis to understand their mechanism of action for the development of possible therapeutics. MDPI 2020-08-24 /pmc/articles/PMC7503277/ /pubmed/32846921 http://dx.doi.org/10.3390/ijms21176081 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Gao, Yongguang Patil, Suryaji Qian, Airong The Role of MicroRNAs in Bone Metabolism and Disease |
title | The Role of MicroRNAs in Bone Metabolism and Disease |
title_full | The Role of MicroRNAs in Bone Metabolism and Disease |
title_fullStr | The Role of MicroRNAs in Bone Metabolism and Disease |
title_full_unstemmed | The Role of MicroRNAs in Bone Metabolism and Disease |
title_short | The Role of MicroRNAs in Bone Metabolism and Disease |
title_sort | role of micrornas in bone metabolism and disease |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7503277/ https://www.ncbi.nlm.nih.gov/pubmed/32846921 http://dx.doi.org/10.3390/ijms21176081 |
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