A GelMA-PEGDA-nHA Composite Hydrogel for Bone Tissue Engineering

A new gelatin methacrylamine (GelMA)-poly (ethylene glycol) diacrylate (PEGDA)-nano hydroxyapatite (nHA) composite hydrogel scaffold was developed using UV photo-crosslinking technology. The Ca(2+) from nHA can form a [HO]Ca(2+) [OH] bridging structure with the hydroxyl group in GelMA, thereby enhan...

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Detalles Bibliográficos
Autores principales: Wang, Yihu, Cao, Xiaofeng, Ma, Ming, Lu, Weipeng, Zhang, Bing, Guo, Yanchuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7503446/
https://www.ncbi.nlm.nih.gov/pubmed/32847000
http://dx.doi.org/10.3390/ma13173735
Descripción
Sumario:A new gelatin methacrylamine (GelMA)-poly (ethylene glycol) diacrylate (PEGDA)-nano hydroxyapatite (nHA) composite hydrogel scaffold was developed using UV photo-crosslinking technology. The Ca(2+) from nHA can form a [HO]Ca(2+) [OH] bridging structure with the hydroxyl group in GelMA, thereby enhancing the stability. Compared with GelMA-PEGDA hydrogel, the addition of nHA can control the mechanical properties of the composite hydrogel and reduce the degradation rate. In vitro cell culture showed that osteoblast can adhere and proliferate on the surface of the hydrogel, indicating that the GelMA-PEGDA-nHA hydrogel had good cell viability and biocompatibility. Furthermore, GelMA-PEGDA-nHA has excellent injectability and rapid prototyping properties and is a promising 3D printed bone repair scaffold material.

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