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Concise Total Synthesis and Antifungal Activities of Fusaric Acid, a Natural Product

The total synthesis of a natural product alkaloid fusaric acid (FA), which exhibits herbicide, fungicide, insecticide and even diverse notable pharmacological activities, was accomplished in four steps using commercially available materials. The synthesis, based on a unified and flexible strategy us...

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Detalles Bibliográficos
Autores principales: Huang, Bin Bin, Liu, Ya Yi, Zhu, Peng Fei, Jiang, Yi Cheng, Ouyang, Ming-An
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7503603/
https://www.ncbi.nlm.nih.gov/pubmed/32854261
http://dx.doi.org/10.3390/molecules25173859
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author Huang, Bin Bin
Liu, Ya Yi
Zhu, Peng Fei
Jiang, Yi Cheng
Ouyang, Ming-An
author_facet Huang, Bin Bin
Liu, Ya Yi
Zhu, Peng Fei
Jiang, Yi Cheng
Ouyang, Ming-An
author_sort Huang, Bin Bin
collection PubMed
description The total synthesis of a natural product alkaloid fusaric acid (FA), which exhibits herbicide, fungicide, insecticide and even diverse notable pharmacological activities, was accomplished in four steps using commercially available materials. The synthesis, based on a unified and flexible strategy using 6-bromonicotinaldehyde as a common intermediate, is concise, convergent, practical and can be carried out on a two-gram scale. This approach could be readily applicable to the synthesis of its analogues. In addition, FA had a wide range of inhibitory activities against 14 plant pathogenic fungi in this study, which demonstrated that as a leading compound, and it has great potential to be further developed as an agricultural fungicide.
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spelling pubmed-75036032020-09-27 Concise Total Synthesis and Antifungal Activities of Fusaric Acid, a Natural Product Huang, Bin Bin Liu, Ya Yi Zhu, Peng Fei Jiang, Yi Cheng Ouyang, Ming-An Molecules Communication The total synthesis of a natural product alkaloid fusaric acid (FA), which exhibits herbicide, fungicide, insecticide and even diverse notable pharmacological activities, was accomplished in four steps using commercially available materials. The synthesis, based on a unified and flexible strategy using 6-bromonicotinaldehyde as a common intermediate, is concise, convergent, practical and can be carried out on a two-gram scale. This approach could be readily applicable to the synthesis of its analogues. In addition, FA had a wide range of inhibitory activities against 14 plant pathogenic fungi in this study, which demonstrated that as a leading compound, and it has great potential to be further developed as an agricultural fungicide. MDPI 2020-08-25 /pmc/articles/PMC7503603/ /pubmed/32854261 http://dx.doi.org/10.3390/molecules25173859 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Communication
Huang, Bin Bin
Liu, Ya Yi
Zhu, Peng Fei
Jiang, Yi Cheng
Ouyang, Ming-An
Concise Total Synthesis and Antifungal Activities of Fusaric Acid, a Natural Product
title Concise Total Synthesis and Antifungal Activities of Fusaric Acid, a Natural Product
title_full Concise Total Synthesis and Antifungal Activities of Fusaric Acid, a Natural Product
title_fullStr Concise Total Synthesis and Antifungal Activities of Fusaric Acid, a Natural Product
title_full_unstemmed Concise Total Synthesis and Antifungal Activities of Fusaric Acid, a Natural Product
title_short Concise Total Synthesis and Antifungal Activities of Fusaric Acid, a Natural Product
title_sort concise total synthesis and antifungal activities of fusaric acid, a natural product
topic Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7503603/
https://www.ncbi.nlm.nih.gov/pubmed/32854261
http://dx.doi.org/10.3390/molecules25173859
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