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Characterization of the Relationship between the Chaperone and Lipid-Binding Functions of the 70-kDa Heat-Shock Protein, HspA1A

HspA1A, a molecular chaperone, translocates to the plasma membrane (PM) of stressed and cancer cells. This translocation results in HspA1A’s cell-surface presentation, which renders tumors radiation insensitive. To specifically inhibit the lipid-driven HspA1A’s PM translocation and devise new therap...

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Detalles Bibliográficos
Autores principales:	Smulders, Larissa, Daniels, Amanda J., Plescia, Caroline B., Berger, Devon, Stahelin, Robert V., Nikolaidis, Nikolas
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7503672/ https://www.ncbi.nlm.nih.gov/pubmed/32825419 http://dx.doi.org/10.3390/ijms21175995

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