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The Anti-ADAMTS-5 Nanobody(®) M6495 Protects Cartilage Degradation Ex Vivo

Osteoarthritis (OA) is associated with cartilage breakdown, brought about by ADAMTS-5 mediated aggrecan degradation followed by MMP-derived aggrecan and type II collagen degradation. We investigated a novel anti-ADAMTS-5 inhibiting Nanobody(®) (M6495) on cartilage turnover ex vivo. Bovine cartilage...

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Detalles Bibliográficos
Autores principales:	Siebuhr, Anne Sofie, Werkmann, Daniela, Bay-Jensen, Anne-C., Thudium, Christian S., Karsdal, Morten Asser, Serruys, Benedikte, Ladel, Christoph, Michaelis, Martin, Lindemann, Sven
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7503673/ https://www.ncbi.nlm.nih.gov/pubmed/32825512 http://dx.doi.org/10.3390/ijms21175992

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