Cargando…

Proteomic Characterization of the Olfactory Molecular Imbalance in Dementia with Lewy Bodies

Olfactory dysfunction is one of the prodromal symptoms in dementia with Lewy bodies (DLB). However, the molecular pathogenesis associated with decreased smell function remains largely undeciphered. We generated quantitative proteome maps to detect molecular alterations in olfactory bulbs (OB) derive...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lachén-Montes, Mercedes, Mendizuri, Naroa, Schvartz, Domitille, Fernández-Irigoyen, Joaquín, Sánchez, Jean Charles, Santamaría, Enrique
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7503830/ https://www.ncbi.nlm.nih.gov/pubmed/32887355 http://dx.doi.org/10.3390/ijms21176371

Ejemplares similares

Amyotrophic Lateral Sclerosis Is Accompanied by Protein Derangements in the Olfactory Bulb-Tract Axis
por: Lachén-Montes, Mercedes, et al.
Publicado: (2020)

Olfactory Bulb Proteomics Reveals Widespread Proteostatic Disturbances in Mixed Dementia and Guides for Potential Serum Biomarkers to Discriminate Alzheimer Disease and Mixed Dementia Phenotypes
por: Lachén-Montes, Mercedes, et al.
Publicado: (2021)

Metabolic dyshomeostasis induced by SARS-CoV-2 structural proteins reveals immunological insights into viral olfactory interactions
por: Lachén-Montes, Mercedes, et al.
Publicado: (2022)

Tackling the Biological Meaning of the Human Olfactory Bulb Dyshomeostatic Proteome across Neurological Disorders: An Integrative Bioinformatic Approach
por: Cartas-Cejudo, Paz, et al.
Publicado: (2021)

Proteomics Insights Into the Molecular Basis of SARS-CoV-2 Infection: What We Can Learn From the Human Olfactory Axis
por: Lachén-Montes, Mercedes, et al.
Publicado: (2020)

Progressive modulation of the human olfactory bulb transcriptome during Alzheimer´s disease evolution: novel insights into the olfactory signaling across proteinopathies
por: Lachen-Montes, Mercedes, et al.
Publicado: (2017)

Sex-divergent effects on the NAD+-dependent deacetylase sirtuin signaling across the olfactory–entorhinal–amygdaloid axis in Alzheimer’s and Parkinson’s diseases
por: Cartas-Cejudo, Paz, et al.
Publicado: (2023)

Network-Driven Proteogenomics Unveils an Aging-Related Imbalance in the Olfactory IκBα-NFκB p65 Complex Functionality in Tg2576 Alzheimer’s Disease Mouse Model
por: Palomino-Alonso, Maialen, et al.
Publicado: (2017)

Cannabis Use Induces Distinctive Proteomic Alterations in Olfactory Neuroepithelial Cells of Schizophrenia Patients
por: Barrera-Conde, Marta, et al.
Publicado: (2021)

Neuroanatomical Quantitative Proteomics Reveals Common Pathogenic Biological Routes between Amyotrophic Lateral Sclerosis (ALS) and Frontotemporal Dementia (FTD)
por: Iridoy, Marina Oaia, et al.
Publicado: (2018)

Olfactory bulb neuroproteomics reveals a chronological perturbation of survival routes and a disruption of prohibitin complex during Alzheimer’s disease progression
por: Lachén-Montes, Mercedes, et al.
Publicado: (2017)

Early-Onset Molecular Derangements in the Olfactory Bulb of Tg2576 Mice: Novel Insights Into the Stress-Responsive Olfactory Kinase Dynamics in Alzheimer’s Disease
por: Lachen-Montes, Mercedes, et al.
Publicado: (2019)

Olfactory proteotyping: towards the enlightenment of the neurodegeneration
por: Fernández-Irigoyen, Joaquín, et al.
Publicado: (2019)

The Human Gastric Juice: A Promising Source for Gastric Cancer Biomarkers
por: Felípez, Nayra, et al.
Publicado: (2023)

Olfactory Characterization and Training in Older Adults: Protocol Study
por: Zambom-Ferraresi, Fabíola, et al.
Publicado: (2021)

A proteomic signature for dementia with Lewy bodies
por: O'Bryant, Sid E., et al.
Publicado: (2019)

The Proteome of Neuromelanin Granules in Dementia with Lewy Bodies
por: Wulf, Maximilian, et al.
Publicado: (2022)

Dysregulated Brain Protein Phosphorylation Linked to Increased Human Tau Expression in the hTau Transgenic Mouse Model
por: Ferrer, Isidro, et al.
Publicado: (2022)

Lewy body disease and dementia with Lewy bodies
por: KOSAKA, Kenji
Publicado: (2014)

Olfactory bulb proteome dynamics during the progression of sporadic Alzheimer's disease: identification of common and distinct olfactory targets across Alzheimer-related co-pathologies
por: Zelaya, María Victoria, et al.
Publicado: (2015)

Dementia with Lewy bodies
por: McKeith, Ian
Publicado: (2004)

Efficacy of Olfactory and Pareidolia Tests Compared With That of Indicative Biomarkers in Diagnosis of Dementia With Lewy Bodies
por: Inagawa, Yuta, et al.
Publicado: (2020)

Alpha-synuclein seeds in olfactory mucosa and cerebrospinal fluid of patients with dementia with Lewy bodies
por: Perra, Daniela, et al.
Publicado: (2021)

Applying mass spectrometry-based qualitative proteomics to human amygdaloid complex
por: Fernández-Irigoyen, Joaquín, et al.
Publicado: (2014)

Contribution of MS-Based Proteomics to the Understanding of Herpes Simplex Virus Type 1 Interaction with Host Cells
por: Santamaría, Enrique, et al.
Publicado: (2012)

Familial globular glial tauopathy linked to MAPT mutations: molecular neuropathology and seeding capacity of a prototypical mixed neuronal and glial tauopathy
por: Ferrer, Isidro, et al.
Publicado: (2020)

Neuroimaging in Lewy body dementia
por: Yousaf, Tayyabah, et al.
Publicado: (2018)

Microbleeds in dementia with Lewy bodies
por: Donaghy, Paul C., et al.
Publicado: (2020)

Advances in dementia with Lewy bodies
por: Armstrong, Melissa J.
Publicado: (2021)

Neuroimaging in Dementia With Lewy Bodies
por: Saha, Abhishikta, et al.
Publicado: (2021)

Anatomo-proteomic characterization of human basal ganglia: focus on striatum and globus pallidus
por: Fernández-Irigoyen, Joaquín, et al.
Publicado: (2014)

Deregulated Transcription and Proteostasis in Adult mapt Knockout Mouse
por: Andrés-Benito, Pol, et al.
Publicado: (2023)

Amyloid-Driven Tau Accumulation on Mitochondria Potentially Leads to Cognitive Deterioration in Alzheimer’s Disease
por: Cuadrado-Tejedor, Mar, et al.
Publicado: (2021)

Neuroimaging characteristics of dementia with Lewy bodies
por: Mak, Elijah, et al.
Publicado: (2014)

Comprehensive treatment of dementia with Lewy bodies
por: Boot, Brendon P
Publicado: (2015)

Neurophysiological biomarkers for Lewy body dementias
por: Cromarty, Ruth A., et al.
Publicado: (2016)

Exome sequencing in dementia with Lewy bodies
por: Keogh, M J, et al.
Publicado: (2016)

Clinical prevalence of Lewy body dementia
por: Kane, Joseph P. M., et al.
Publicado: (2018)

Dementia with Lewy bodies: an update and outlook
por: Outeiro, Tiago Fleming, et al.
Publicado: (2019)

Young-Onset Dementia with Lewy Bodies
por: Aiba, Yosuke, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_4su9uebgi7fkhni15oo985u9sp