Wnt Signaling in Leukemia and Its Bone Marrow Microenvironment

Leukemia is an aggressive hematologic neoplastic disease. Therapy-resistant leukemic stem cells (LSCs) may contribute to the relapse of the disease. LSCs are thought to be protected in the leukemia microenvironment, mainly consisting of mesenchymal stem/stromal cells (MSC), endothelial cells, and os...

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Detalles Bibliográficos
Autores principales: Ruan, Yongsheng, Kim, Hye Na, Ogana, Heather, Kim, Yong-Mi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7503842/
https://www.ncbi.nlm.nih.gov/pubmed/32872365
http://dx.doi.org/10.3390/ijms21176247
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author Ruan, Yongsheng
Kim, Hye Na
Ogana, Heather
Kim, Yong-Mi
author_facet Ruan, Yongsheng
Kim, Hye Na
Ogana, Heather
Kim, Yong-Mi
author_sort Ruan, Yongsheng
collection PubMed
description Leukemia is an aggressive hematologic neoplastic disease. Therapy-resistant leukemic stem cells (LSCs) may contribute to the relapse of the disease. LSCs are thought to be protected in the leukemia microenvironment, mainly consisting of mesenchymal stem/stromal cells (MSC), endothelial cells, and osteoblasts. Canonical and noncanonical Wnt pathways play a critical role in the maintenance of normal hematopoietic stem cells (HSC) and LSCs. In this review, we summarize recent findings on the role of Wnt signaling in leukemia and its microenvironment and provide information on the currently available strategies for targeting Wnt signaling.
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spelling pubmed-75038422020-09-27 Wnt Signaling in Leukemia and Its Bone Marrow Microenvironment Ruan, Yongsheng Kim, Hye Na Ogana, Heather Kim, Yong-Mi Int J Mol Sci Review Leukemia is an aggressive hematologic neoplastic disease. Therapy-resistant leukemic stem cells (LSCs) may contribute to the relapse of the disease. LSCs are thought to be protected in the leukemia microenvironment, mainly consisting of mesenchymal stem/stromal cells (MSC), endothelial cells, and osteoblasts. Canonical and noncanonical Wnt pathways play a critical role in the maintenance of normal hematopoietic stem cells (HSC) and LSCs. In this review, we summarize recent findings on the role of Wnt signaling in leukemia and its microenvironment and provide information on the currently available strategies for targeting Wnt signaling. MDPI 2020-08-28 /pmc/articles/PMC7503842/ /pubmed/32872365 http://dx.doi.org/10.3390/ijms21176247 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Ruan, Yongsheng
Kim, Hye Na
Ogana, Heather
Kim, Yong-Mi
Wnt Signaling in Leukemia and Its Bone Marrow Microenvironment
title Wnt Signaling in Leukemia and Its Bone Marrow Microenvironment
title_full Wnt Signaling in Leukemia and Its Bone Marrow Microenvironment
title_fullStr Wnt Signaling in Leukemia and Its Bone Marrow Microenvironment
title_full_unstemmed Wnt Signaling in Leukemia and Its Bone Marrow Microenvironment
title_short Wnt Signaling in Leukemia and Its Bone Marrow Microenvironment
title_sort wnt signaling in leukemia and its bone marrow microenvironment
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7503842/
https://www.ncbi.nlm.nih.gov/pubmed/32872365
http://dx.doi.org/10.3390/ijms21176247
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AT kimhyena wntsignalinginleukemiaanditsbonemarrowmicroenvironment
AT oganaheather wntsignalinginleukemiaanditsbonemarrowmicroenvironment
AT kimyongmi wntsignalinginleukemiaanditsbonemarrowmicroenvironment

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