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The Endosomal Recycling Pathway—At the Crossroads of the Cell

The endosomal recycling pathway lies at the heart of the membrane trafficking machinery in the cell. It plays a central role in determining the composition of the plasma membrane and is thus critical for normal cellular homeostasis. However, defective endosomal recycling has been linked to a wide ra...

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Detalles Bibliográficos
Autores principales: O’Sullivan, Mary J., Lindsay, Andrew J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7503921/
https://www.ncbi.nlm.nih.gov/pubmed/32842549
http://dx.doi.org/10.3390/ijms21176074
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author O’Sullivan, Mary J.
Lindsay, Andrew J.
author_facet O’Sullivan, Mary J.
Lindsay, Andrew J.
author_sort O’Sullivan, Mary J.
collection PubMed
description The endosomal recycling pathway lies at the heart of the membrane trafficking machinery in the cell. It plays a central role in determining the composition of the plasma membrane and is thus critical for normal cellular homeostasis. However, defective endosomal recycling has been linked to a wide range of diseases, including cancer and some of the most common neurological disorders. It is also frequently subverted by many diverse human pathogens in order to successfully infect cells. Despite its importance, endosomal recycling remains relatively understudied in comparison to the endocytic and secretory transport pathways. A greater understanding of the molecular mechanisms that support transport through the endosomal recycling pathway will provide deeper insights into the pathophysiology of disease and will likely identify new approaches for their detection and treatment. This review will provide an overview of the normal physiological role of the endosomal recycling pathway, describe the consequences when it malfunctions, and discuss potential strategies for modulating its activity.
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spelling pubmed-75039212020-09-27 The Endosomal Recycling Pathway—At the Crossroads of the Cell O’Sullivan, Mary J. Lindsay, Andrew J. Int J Mol Sci Review The endosomal recycling pathway lies at the heart of the membrane trafficking machinery in the cell. It plays a central role in determining the composition of the plasma membrane and is thus critical for normal cellular homeostasis. However, defective endosomal recycling has been linked to a wide range of diseases, including cancer and some of the most common neurological disorders. It is also frequently subverted by many diverse human pathogens in order to successfully infect cells. Despite its importance, endosomal recycling remains relatively understudied in comparison to the endocytic and secretory transport pathways. A greater understanding of the molecular mechanisms that support transport through the endosomal recycling pathway will provide deeper insights into the pathophysiology of disease and will likely identify new approaches for their detection and treatment. This review will provide an overview of the normal physiological role of the endosomal recycling pathway, describe the consequences when it malfunctions, and discuss potential strategies for modulating its activity. MDPI 2020-08-23 /pmc/articles/PMC7503921/ /pubmed/32842549 http://dx.doi.org/10.3390/ijms21176074 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
O’Sullivan, Mary J.
Lindsay, Andrew J.
The Endosomal Recycling Pathway—At the Crossroads of the Cell
title The Endosomal Recycling Pathway—At the Crossroads of the Cell
title_full The Endosomal Recycling Pathway—At the Crossroads of the Cell
title_fullStr The Endosomal Recycling Pathway—At the Crossroads of the Cell
title_full_unstemmed The Endosomal Recycling Pathway—At the Crossroads of the Cell
title_short The Endosomal Recycling Pathway—At the Crossroads of the Cell
title_sort endosomal recycling pathway—at the crossroads of the cell
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7503921/
https://www.ncbi.nlm.nih.gov/pubmed/32842549
http://dx.doi.org/10.3390/ijms21176074
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