Intratumoral Distribution and pH-Dependent Drug Release of High Molecular Weight HPMA Copolymer Drug Conjugates Strongly Depend on Specific Tumor Substructure and Microenvironment

Stimulus-sensitive polymer drug conjugates based on high molecular weight N-(2-hydroxypropyl) methacrylamide (HPMA) copolymers carrying doxorubicin via a pH-dependent cleavable bond (pHPMA-Dox) were previously shown to be able to overcome multi-drug resistance. Nevertheless, a tumor type dependent d...

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Detalles Bibliográficos
Autores principales: Noack, Anne-Kathrin, Lucas, Henrike, Chytil, Petr, Etrych, Tomáš, Mäder, Karsten, Mueller, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7504030/
https://www.ncbi.nlm.nih.gov/pubmed/32825790
http://dx.doi.org/10.3390/ijms21176029

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7504030/
https://www.ncbi.nlm.nih.gov/pubmed/32825790
http://dx.doi.org/10.3390/ijms21176029

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