Tetrapeptide Ac-HAEE-NH(2) Protects α4β2 nAChR from Inhibition by Aβ

The cholinergic deficit in Alzheimer’s disease (AD) may arise from selective loss of cholinergic neurons caused by the binding of Aβ peptide to nicotinic acetylcholine receptors (nAChRs). Thus, compounds preventing such an interaction are needed to address the cholinergic dysfunction. Recent finding...

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Detalles Bibliográficos
Autores principales: Barykin, Evgeny P., Garifulina, Aleksandra I., Tolstova, Anna P., Anashkina, Anastasia A., Adzhubei, Alexei A., Mezentsev, Yuri V., Shelukhina, Irina V., Kozin, Sergey A., Tsetlin, Victor I., Makarov, Alexander A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7504039/
https://www.ncbi.nlm.nih.gov/pubmed/32872553
http://dx.doi.org/10.3390/ijms21176272

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7504039/
https://www.ncbi.nlm.nih.gov/pubmed/32872553
http://dx.doi.org/10.3390/ijms21176272

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