“Clicking” an Ionic Liquid to a Potent Antimicrobial Peptide: On the Route towards Improved Stability

A covalent conjugate between an antibacterial ionic liquid and an antimicrobial peptide was produced via “click” chemistry, and found to retain the parent peptide’s activity against multidrug-resistant clinical isolates of Gram-negative bacteria, and antibiofilm action on a resistant clinical isolat...

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Detalles Bibliográficos
Autores principales: Gomes, Ana, Bessa, Lucinda J., Correia, Patrícia, Fernandes, Iva, Ferraz, Ricardo, Gameiro, Paula, Teixeira, Cátia, Gomes, Paula
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7504088/
https://www.ncbi.nlm.nih.gov/pubmed/32859111
http://dx.doi.org/10.3390/ijms21176174
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author Gomes, Ana
Bessa, Lucinda J.
Correia, Patrícia
Fernandes, Iva
Ferraz, Ricardo
Gameiro, Paula
Teixeira, Cátia
Gomes, Paula
author_facet Gomes, Ana
Bessa, Lucinda J.
Correia, Patrícia
Fernandes, Iva
Ferraz, Ricardo
Gameiro, Paula
Teixeira, Cátia
Gomes, Paula
author_sort Gomes, Ana
collection PubMed
description A covalent conjugate between an antibacterial ionic liquid and an antimicrobial peptide was produced via “click” chemistry, and found to retain the parent peptide’s activity against multidrug-resistant clinical isolates of Gram-negative bacteria, and antibiofilm action on a resistant clinical isolate of Klebsiella pneumoniae, while exhibiting much improved stability towards tyrosinase-mediated modifications. This unprecedented communication is a prelude for the promise held by ionic liquids -based approaches as tools to improve the action of bioactive peptides.
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spelling pubmed-75040882020-09-24 “Clicking” an Ionic Liquid to a Potent Antimicrobial Peptide: On the Route towards Improved Stability Gomes, Ana Bessa, Lucinda J. Correia, Patrícia Fernandes, Iva Ferraz, Ricardo Gameiro, Paula Teixeira, Cátia Gomes, Paula Int J Mol Sci Communication A covalent conjugate between an antibacterial ionic liquid and an antimicrobial peptide was produced via “click” chemistry, and found to retain the parent peptide’s activity against multidrug-resistant clinical isolates of Gram-negative bacteria, and antibiofilm action on a resistant clinical isolate of Klebsiella pneumoniae, while exhibiting much improved stability towards tyrosinase-mediated modifications. This unprecedented communication is a prelude for the promise held by ionic liquids -based approaches as tools to improve the action of bioactive peptides. MDPI 2020-08-26 /pmc/articles/PMC7504088/ /pubmed/32859111 http://dx.doi.org/10.3390/ijms21176174 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Communication
Gomes, Ana
Bessa, Lucinda J.
Correia, Patrícia
Fernandes, Iva
Ferraz, Ricardo
Gameiro, Paula
Teixeira, Cátia
Gomes, Paula
“Clicking” an Ionic Liquid to a Potent Antimicrobial Peptide: On the Route towards Improved Stability
title “Clicking” an Ionic Liquid to a Potent Antimicrobial Peptide: On the Route towards Improved Stability
title_full “Clicking” an Ionic Liquid to a Potent Antimicrobial Peptide: On the Route towards Improved Stability
title_fullStr “Clicking” an Ionic Liquid to a Potent Antimicrobial Peptide: On the Route towards Improved Stability
title_full_unstemmed “Clicking” an Ionic Liquid to a Potent Antimicrobial Peptide: On the Route towards Improved Stability
title_short “Clicking” an Ionic Liquid to a Potent Antimicrobial Peptide: On the Route towards Improved Stability
title_sort “clicking” an ionic liquid to a potent antimicrobial peptide: on the route towards improved stability
topic Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7504088/
https://www.ncbi.nlm.nih.gov/pubmed/32859111
http://dx.doi.org/10.3390/ijms21176174
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