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Copper(II) Complexes with Mixed Heterocycle Ligands as Promising Antibacterial and Antitumor Species

Complexes with mixed ligands [Cu(N-N)(2)(pmtp)](ClO(4))(2) ((1) N-N: 2,2′-bipyridine; (2) L: 1,10-phenanthroline and pmpt: 5-phenyl-7-methyl-1,2,4-triazolo[1,5-a]pyrimidine) were synthesized and structurally and biologically characterized. Compound (1) crystallizes into space group Pa and (2) in P-1...

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Autores principales: Rostas, Arpad Mihai, Badea, Mihaela, Ruta, Lavinia L., Farcasanu, Ileana C., Maxim, Catalin, Chifiriuc, Mariana Carmen, Popa, Marcela, Luca, Mirela, Celan Korosin, Natasa, Cerc Korosec, Romana, Bacalum, Mihaela, Raileanu, Mina, Olar, Rodica
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7504215/
https://www.ncbi.nlm.nih.gov/pubmed/32825156
http://dx.doi.org/10.3390/molecules25173777
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author Rostas, Arpad Mihai
Badea, Mihaela
Ruta, Lavinia L.
Farcasanu, Ileana C.
Maxim, Catalin
Chifiriuc, Mariana Carmen
Popa, Marcela
Luca, Mirela
Celan Korosin, Natasa
Cerc Korosec, Romana
Bacalum, Mihaela
Raileanu, Mina
Olar, Rodica
author_facet Rostas, Arpad Mihai
Badea, Mihaela
Ruta, Lavinia L.
Farcasanu, Ileana C.
Maxim, Catalin
Chifiriuc, Mariana Carmen
Popa, Marcela
Luca, Mirela
Celan Korosin, Natasa
Cerc Korosec, Romana
Bacalum, Mihaela
Raileanu, Mina
Olar, Rodica
author_sort Rostas, Arpad Mihai
collection PubMed
description Complexes with mixed ligands [Cu(N-N)(2)(pmtp)](ClO(4))(2) ((1) N-N: 2,2′-bipyridine; (2) L: 1,10-phenanthroline and pmpt: 5-phenyl-7-methyl-1,2,4-triazolo[1,5-a]pyrimidine) were synthesized and structurally and biologically characterized. Compound (1) crystallizes into space group Pa and (2) in P-1. Both complexes display an intermediate stereochemistry between the two five-coordinated ones. The biological tests indicated that the two compounds exhibited superoxide scavenging capacity, intercalative DNA properties, and metallonuclease activity. Tests on various cell systems indicated that the two complexes neither interfere with the proliferation of Saccharomyces cerevisiae or BJ healthy skin cells, nor cause hemolysis in the active concentration range. Nevertheless, the compounds showed antibacterial potential, with complex (2) being significantly more active than complex (1) against all tested bacterial strains, both in planktonic and biofilm growth state. Both complexes exhibited a very good activity against B16 melanoma cells, with a higher specificity being displayed by compound (1). Taken together, the results indicate that complexes (1) and (2) have specific biological relevance, with potential for the development of antitumor or antimicrobial drugs.
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spelling pubmed-75042152020-09-24 Copper(II) Complexes with Mixed Heterocycle Ligands as Promising Antibacterial and Antitumor Species Rostas, Arpad Mihai Badea, Mihaela Ruta, Lavinia L. Farcasanu, Ileana C. Maxim, Catalin Chifiriuc, Mariana Carmen Popa, Marcela Luca, Mirela Celan Korosin, Natasa Cerc Korosec, Romana Bacalum, Mihaela Raileanu, Mina Olar, Rodica Molecules Article Complexes with mixed ligands [Cu(N-N)(2)(pmtp)](ClO(4))(2) ((1) N-N: 2,2′-bipyridine; (2) L: 1,10-phenanthroline and pmpt: 5-phenyl-7-methyl-1,2,4-triazolo[1,5-a]pyrimidine) were synthesized and structurally and biologically characterized. Compound (1) crystallizes into space group Pa and (2) in P-1. Both complexes display an intermediate stereochemistry between the two five-coordinated ones. The biological tests indicated that the two compounds exhibited superoxide scavenging capacity, intercalative DNA properties, and metallonuclease activity. Tests on various cell systems indicated that the two complexes neither interfere with the proliferation of Saccharomyces cerevisiae or BJ healthy skin cells, nor cause hemolysis in the active concentration range. Nevertheless, the compounds showed antibacterial potential, with complex (2) being significantly more active than complex (1) against all tested bacterial strains, both in planktonic and biofilm growth state. Both complexes exhibited a very good activity against B16 melanoma cells, with a higher specificity being displayed by compound (1). Taken together, the results indicate that complexes (1) and (2) have specific biological relevance, with potential for the development of antitumor or antimicrobial drugs. MDPI 2020-08-19 /pmc/articles/PMC7504215/ /pubmed/32825156 http://dx.doi.org/10.3390/molecules25173777 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Rostas, Arpad Mihai
Badea, Mihaela
Ruta, Lavinia L.
Farcasanu, Ileana C.
Maxim, Catalin
Chifiriuc, Mariana Carmen
Popa, Marcela
Luca, Mirela
Celan Korosin, Natasa
Cerc Korosec, Romana
Bacalum, Mihaela
Raileanu, Mina
Olar, Rodica
Copper(II) Complexes with Mixed Heterocycle Ligands as Promising Antibacterial and Antitumor Species
title Copper(II) Complexes with Mixed Heterocycle Ligands as Promising Antibacterial and Antitumor Species
title_full Copper(II) Complexes with Mixed Heterocycle Ligands as Promising Antibacterial and Antitumor Species
title_fullStr Copper(II) Complexes with Mixed Heterocycle Ligands as Promising Antibacterial and Antitumor Species
title_full_unstemmed Copper(II) Complexes with Mixed Heterocycle Ligands as Promising Antibacterial and Antitumor Species
title_short Copper(II) Complexes with Mixed Heterocycle Ligands as Promising Antibacterial and Antitumor Species
title_sort copper(ii) complexes with mixed heterocycle ligands as promising antibacterial and antitumor species
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7504215/
https://www.ncbi.nlm.nih.gov/pubmed/32825156
http://dx.doi.org/10.3390/molecules25173777
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