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Evaluation of Nonresponse Bias in a Case–Control Study of Pleural Mesothelioma

Nonparticipation limits the power of epidemiological studies, and can cause bias. In a case–control study on pleural malignant mesothelioma (MM), we found low participation in interviews (63%) among controls. Our goal was to characterize nonresponder controls and assess nonresponse bias in our study...

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Autores principales: Airoldi, Chiara, Ferrante, Daniela, Mirabelli, Dario, Azzolina, Danila, Magnani, Corrado
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7504238/
https://www.ncbi.nlm.nih.gov/pubmed/32847019
http://dx.doi.org/10.3390/ijerph17176146
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author Airoldi, Chiara
Ferrante, Daniela
Mirabelli, Dario
Azzolina, Danila
Magnani, Corrado
author_facet Airoldi, Chiara
Ferrante, Daniela
Mirabelli, Dario
Azzolina, Danila
Magnani, Corrado
author_sort Airoldi, Chiara
collection PubMed
description Nonparticipation limits the power of epidemiological studies, and can cause bias. In a case–control study on pleural malignant mesothelioma (MM), we found low participation in interviews (63%) among controls. Our goal was to characterize nonresponder controls and assess nonresponse bias in our study. We selected all nonresponder controls (204) and a random sample of responder controls (174). Data were obtained linking hospital admissions and town registrars, and concordance between sources was assessed. Nonresponse bias was evaluated using a logistic regression model applying the inverse probability weighting approach. The odds ratio (OR) for the status of the respondents was 0.61 (95% confidence interval (CI): 0.33–1.16) for controls aged 61–70, 0.37 (CI: 0.20–0.66) for those aged 71–80, and 0.40 (CI: 0.20–0.80) for those aged above 80 (reference group: ≤60 years). Controls with low education level had lower OR (0.47; CI: 0.26–0.84). After adjustment, the ORs for MM by categories of cumulative exposure to asbestos were similar to the unadjusted results, ranging from 4.6 (CI: 1.8–11.7) for cumulative exposures between 0.1 and 1 f/mL-y to 57.5 (CI: 20.2–163.9) above 10 f/mL-y. Responder controls were younger and had higher education level. Nevertheless, there was little evidence of bias from nonresponse in the risk estimates of MM.
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spelling pubmed-75042382020-09-24 Evaluation of Nonresponse Bias in a Case–Control Study of Pleural Mesothelioma Airoldi, Chiara Ferrante, Daniela Mirabelli, Dario Azzolina, Danila Magnani, Corrado Int J Environ Res Public Health Article Nonparticipation limits the power of epidemiological studies, and can cause bias. In a case–control study on pleural malignant mesothelioma (MM), we found low participation in interviews (63%) among controls. Our goal was to characterize nonresponder controls and assess nonresponse bias in our study. We selected all nonresponder controls (204) and a random sample of responder controls (174). Data were obtained linking hospital admissions and town registrars, and concordance between sources was assessed. Nonresponse bias was evaluated using a logistic regression model applying the inverse probability weighting approach. The odds ratio (OR) for the status of the respondents was 0.61 (95% confidence interval (CI): 0.33–1.16) for controls aged 61–70, 0.37 (CI: 0.20–0.66) for those aged 71–80, and 0.40 (CI: 0.20–0.80) for those aged above 80 (reference group: ≤60 years). Controls with low education level had lower OR (0.47; CI: 0.26–0.84). After adjustment, the ORs for MM by categories of cumulative exposure to asbestos were similar to the unadjusted results, ranging from 4.6 (CI: 1.8–11.7) for cumulative exposures between 0.1 and 1 f/mL-y to 57.5 (CI: 20.2–163.9) above 10 f/mL-y. Responder controls were younger and had higher education level. Nevertheless, there was little evidence of bias from nonresponse in the risk estimates of MM. MDPI 2020-08-24 2020-09 /pmc/articles/PMC7504238/ /pubmed/32847019 http://dx.doi.org/10.3390/ijerph17176146 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Airoldi, Chiara
Ferrante, Daniela
Mirabelli, Dario
Azzolina, Danila
Magnani, Corrado
Evaluation of Nonresponse Bias in a Case–Control Study of Pleural Mesothelioma
title Evaluation of Nonresponse Bias in a Case–Control Study of Pleural Mesothelioma
title_full Evaluation of Nonresponse Bias in a Case–Control Study of Pleural Mesothelioma
title_fullStr Evaluation of Nonresponse Bias in a Case–Control Study of Pleural Mesothelioma
title_full_unstemmed Evaluation of Nonresponse Bias in a Case–Control Study of Pleural Mesothelioma
title_short Evaluation of Nonresponse Bias in a Case–Control Study of Pleural Mesothelioma
title_sort evaluation of nonresponse bias in a case–control study of pleural mesothelioma
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7504238/
https://www.ncbi.nlm.nih.gov/pubmed/32847019
http://dx.doi.org/10.3390/ijerph17176146
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