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Evaluation of Nonresponse Bias in a Case–Control Study of Pleural Mesothelioma
Nonparticipation limits the power of epidemiological studies, and can cause bias. In a case–control study on pleural malignant mesothelioma (MM), we found low participation in interviews (63%) among controls. Our goal was to characterize nonresponder controls and assess nonresponse bias in our study...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7504238/ https://www.ncbi.nlm.nih.gov/pubmed/32847019 http://dx.doi.org/10.3390/ijerph17176146 |
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author | Airoldi, Chiara Ferrante, Daniela Mirabelli, Dario Azzolina, Danila Magnani, Corrado |
author_facet | Airoldi, Chiara Ferrante, Daniela Mirabelli, Dario Azzolina, Danila Magnani, Corrado |
author_sort | Airoldi, Chiara |
collection | PubMed |
description | Nonparticipation limits the power of epidemiological studies, and can cause bias. In a case–control study on pleural malignant mesothelioma (MM), we found low participation in interviews (63%) among controls. Our goal was to characterize nonresponder controls and assess nonresponse bias in our study. We selected all nonresponder controls (204) and a random sample of responder controls (174). Data were obtained linking hospital admissions and town registrars, and concordance between sources was assessed. Nonresponse bias was evaluated using a logistic regression model applying the inverse probability weighting approach. The odds ratio (OR) for the status of the respondents was 0.61 (95% confidence interval (CI): 0.33–1.16) for controls aged 61–70, 0.37 (CI: 0.20–0.66) for those aged 71–80, and 0.40 (CI: 0.20–0.80) for those aged above 80 (reference group: ≤60 years). Controls with low education level had lower OR (0.47; CI: 0.26–0.84). After adjustment, the ORs for MM by categories of cumulative exposure to asbestos were similar to the unadjusted results, ranging from 4.6 (CI: 1.8–11.7) for cumulative exposures between 0.1 and 1 f/mL-y to 57.5 (CI: 20.2–163.9) above 10 f/mL-y. Responder controls were younger and had higher education level. Nevertheless, there was little evidence of bias from nonresponse in the risk estimates of MM. |
format | Online Article Text |
id | pubmed-7504238 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-75042382020-09-24 Evaluation of Nonresponse Bias in a Case–Control Study of Pleural Mesothelioma Airoldi, Chiara Ferrante, Daniela Mirabelli, Dario Azzolina, Danila Magnani, Corrado Int J Environ Res Public Health Article Nonparticipation limits the power of epidemiological studies, and can cause bias. In a case–control study on pleural malignant mesothelioma (MM), we found low participation in interviews (63%) among controls. Our goal was to characterize nonresponder controls and assess nonresponse bias in our study. We selected all nonresponder controls (204) and a random sample of responder controls (174). Data were obtained linking hospital admissions and town registrars, and concordance between sources was assessed. Nonresponse bias was evaluated using a logistic regression model applying the inverse probability weighting approach. The odds ratio (OR) for the status of the respondents was 0.61 (95% confidence interval (CI): 0.33–1.16) for controls aged 61–70, 0.37 (CI: 0.20–0.66) for those aged 71–80, and 0.40 (CI: 0.20–0.80) for those aged above 80 (reference group: ≤60 years). Controls with low education level had lower OR (0.47; CI: 0.26–0.84). After adjustment, the ORs for MM by categories of cumulative exposure to asbestos were similar to the unadjusted results, ranging from 4.6 (CI: 1.8–11.7) for cumulative exposures between 0.1 and 1 f/mL-y to 57.5 (CI: 20.2–163.9) above 10 f/mL-y. Responder controls were younger and had higher education level. Nevertheless, there was little evidence of bias from nonresponse in the risk estimates of MM. MDPI 2020-08-24 2020-09 /pmc/articles/PMC7504238/ /pubmed/32847019 http://dx.doi.org/10.3390/ijerph17176146 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Airoldi, Chiara Ferrante, Daniela Mirabelli, Dario Azzolina, Danila Magnani, Corrado Evaluation of Nonresponse Bias in a Case–Control Study of Pleural Mesothelioma |
title | Evaluation of Nonresponse Bias in a Case–Control Study of Pleural Mesothelioma |
title_full | Evaluation of Nonresponse Bias in a Case–Control Study of Pleural Mesothelioma |
title_fullStr | Evaluation of Nonresponse Bias in a Case–Control Study of Pleural Mesothelioma |
title_full_unstemmed | Evaluation of Nonresponse Bias in a Case–Control Study of Pleural Mesothelioma |
title_short | Evaluation of Nonresponse Bias in a Case–Control Study of Pleural Mesothelioma |
title_sort | evaluation of nonresponse bias in a case–control study of pleural mesothelioma |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7504238/ https://www.ncbi.nlm.nih.gov/pubmed/32847019 http://dx.doi.org/10.3390/ijerph17176146 |
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