New Hybrids of 4-Amino-2,3-polymethylene-quinoline and p-Tolylsulfonamide as Dual Inhibitors of Acetyl- and Butyrylcholinesterase and Potential Multifunctional Agents for Alzheimer’s Disease Treatment

New hybrid compounds of 4-amino-2,3-polymethylene-quinoline containing different sizes of the aliphatic ring and linked to p-tolylsulfonamide with alkylene spacers of increasing length were synthesized as potential drugs for treatment of Alzheimer’s disease (AD). All compounds were potent inhibitors...

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Detalles Bibliográficos
Autores principales: Makhaeva, Galina F., Kovaleva, Nadezhda V., Boltneva, Natalia P., Lushchekina, Sofya V., Astakhova, Tatiana Yu., Rudakova, Elena V., Proshin, Alexey N., Serkov, Igor V., Radchenko, Eugene V., Palyulin, Vladimir A., Bachurin, Sergey O., Richardson, Rudy J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7504258/
https://www.ncbi.nlm.nih.gov/pubmed/32867324
http://dx.doi.org/10.3390/molecules25173915

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7504258/
https://www.ncbi.nlm.nih.gov/pubmed/32867324
http://dx.doi.org/10.3390/molecules25173915

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