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In Silico Finding of Key Interaction Mediated α3β4 and α7 Nicotinic Acetylcholine Receptor Ligand Selectivity of Quinuclidine-Triazole Chemotype

The selective binding of six (S)-quinuclidine-triazoles and their (R)-enantiomers to nicotinic acetylcholine receptor (nAChR) subtypes α3β4 and α7, respectively, were analyzed by in silico docking to provide the insight into the molecular basis for the observed stereospecific subtype discrimination....

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Detalles Bibliográficos
Autores principales:	Arunrungvichian, Kuntarat, Chongruchiroj, Sumet, Sarasamkan, Jiradanai, Schüürmann, Gerrit, Brust, Peter, Vajragupta, Opa
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7504379/ https://www.ncbi.nlm.nih.gov/pubmed/32867140 http://dx.doi.org/10.3390/ijms21176189

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