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Targeting Adaptive IRE1α Signaling and PLK2 in Multiple Myeloma: Possible Anti-Tumor Mechanisms of KIRA8 and Nilotinib

Background: Inositol-requiring enzyme 1α (IRE1α), along with protein kinase R-like endoplasmic reticulum kinase (PERK), is a principal regulator of the unfolded protein response (UPR). Recently, the ‘mono’-specific IRE1α inhibitor, kinase-inhibiting RNase attenuator 6 (KIRA6), demonstrated a promisi...

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Detalles Bibliográficos
Autores principales:	Yamashita, Yusuke, Morita, Shuhei, Hosoi, Hiroki, Kobata, Hiroshi, Kishimoto, Shohei, Ishibashi, Tatsuya, Mishima, Hiroyuki, Kinoshita, Akira, Backes, Bradley J., Yoshiura, Koh-Ichiro, Papa, Feroz R., Sonoki, Takashi, Tamura, Shinobu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7504392/ https://www.ncbi.nlm.nih.gov/pubmed/32878237 http://dx.doi.org/10.3390/ijms21176314

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