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Epigenetic Mechanisms Underlying Adult Post Stroke Neurogenesis
Stroke remains the leading cause of adult disability. Post-stroke neurogenesis contributes to functional recovery. As an intrinsic neurorestorative process, it is important to elucidate the molecular mechanism underlying stroke-induced neurogenesis and to develop therapies designed specifically to a...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7504398/ https://www.ncbi.nlm.nih.gov/pubmed/32867041 http://dx.doi.org/10.3390/ijms21176179 |
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author | Liu, Xianshuang Fan, Baoyan Chopp, Michael Zhang, Zhenggang |
author_facet | Liu, Xianshuang Fan, Baoyan Chopp, Michael Zhang, Zhenggang |
author_sort | Liu, Xianshuang |
collection | PubMed |
description | Stroke remains the leading cause of adult disability. Post-stroke neurogenesis contributes to functional recovery. As an intrinsic neurorestorative process, it is important to elucidate the molecular mechanism underlying stroke-induced neurogenesis and to develop therapies designed specifically to augment neurogenesis. Epigenetic mechanisms include DNA methylation, histone modification and its mediation by microRNAs and long-non-coding RNAs. In this review, we highlight how epigenetic factors including DNA methylation, histone modification, microRNAs and long-non-coding RNAs mediate stroke-induced neurogenesis including neural stem cell self-renewal and cell fate determination. We also summarize therapies targeting these mechanisms in the treatment of stroke. |
format | Online Article Text |
id | pubmed-7504398 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-75043982020-09-24 Epigenetic Mechanisms Underlying Adult Post Stroke Neurogenesis Liu, Xianshuang Fan, Baoyan Chopp, Michael Zhang, Zhenggang Int J Mol Sci Review Stroke remains the leading cause of adult disability. Post-stroke neurogenesis contributes to functional recovery. As an intrinsic neurorestorative process, it is important to elucidate the molecular mechanism underlying stroke-induced neurogenesis and to develop therapies designed specifically to augment neurogenesis. Epigenetic mechanisms include DNA methylation, histone modification and its mediation by microRNAs and long-non-coding RNAs. In this review, we highlight how epigenetic factors including DNA methylation, histone modification, microRNAs and long-non-coding RNAs mediate stroke-induced neurogenesis including neural stem cell self-renewal and cell fate determination. We also summarize therapies targeting these mechanisms in the treatment of stroke. MDPI 2020-08-27 /pmc/articles/PMC7504398/ /pubmed/32867041 http://dx.doi.org/10.3390/ijms21176179 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Liu, Xianshuang Fan, Baoyan Chopp, Michael Zhang, Zhenggang Epigenetic Mechanisms Underlying Adult Post Stroke Neurogenesis |
title | Epigenetic Mechanisms Underlying Adult Post Stroke Neurogenesis |
title_full | Epigenetic Mechanisms Underlying Adult Post Stroke Neurogenesis |
title_fullStr | Epigenetic Mechanisms Underlying Adult Post Stroke Neurogenesis |
title_full_unstemmed | Epigenetic Mechanisms Underlying Adult Post Stroke Neurogenesis |
title_short | Epigenetic Mechanisms Underlying Adult Post Stroke Neurogenesis |
title_sort | epigenetic mechanisms underlying adult post stroke neurogenesis |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7504398/ https://www.ncbi.nlm.nih.gov/pubmed/32867041 http://dx.doi.org/10.3390/ijms21176179 |
work_keys_str_mv | AT liuxianshuang epigeneticmechanismsunderlyingadultpoststrokeneurogenesis AT fanbaoyan epigeneticmechanismsunderlyingadultpoststrokeneurogenesis AT choppmichael epigeneticmechanismsunderlyingadultpoststrokeneurogenesis AT zhangzhenggang epigeneticmechanismsunderlyingadultpoststrokeneurogenesis |