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Valuing Bioactive Lipids from Green, Red and Brown Macroalgae from Aquaculture, to Foster Functionality and Biotechnological Applications

Marine edible macroalgae have functional proprieties that might improve human health and wellbeing. Lipids represent a minor fraction of macroalgae, yet with major interest as main carriers of omega 3 polyunsaturated fatty acids and intrinsic bioactive properties. In this study, we used lipid extrac...

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Autores principales: Lopes, Diana, Melo, Tânia, Rey, Felisa, Meneses, Joana, Monteiro, Fátima Liliana, Helguero, Luisa A., Abreu, Maria Helena, Lillebø, Ana Isabel, Calado, Ricardo, Domingues, Maria Rosário
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7504498/
https://www.ncbi.nlm.nih.gov/pubmed/32858862
http://dx.doi.org/10.3390/molecules25173883
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author Lopes, Diana
Melo, Tânia
Rey, Felisa
Meneses, Joana
Monteiro, Fátima Liliana
Helguero, Luisa A.
Abreu, Maria Helena
Lillebø, Ana Isabel
Calado, Ricardo
Domingues, Maria Rosário
author_facet Lopes, Diana
Melo, Tânia
Rey, Felisa
Meneses, Joana
Monteiro, Fátima Liliana
Helguero, Luisa A.
Abreu, Maria Helena
Lillebø, Ana Isabel
Calado, Ricardo
Domingues, Maria Rosário
author_sort Lopes, Diana
collection PubMed
description Marine edible macroalgae have functional proprieties that might improve human health and wellbeing. Lipids represent a minor fraction of macroalgae, yet with major interest as main carriers of omega 3 polyunsaturated fatty acids and intrinsic bioactive properties. In this study, we used lipid extracts from the green macroalgae Ulva rigida and Codium tomentosum; the red Gracilaria gracilis, Palmaria palmata and Porphyra dioica; and the brown Fucus vesiculosus, produced in a land-based integrated multitrophic aquaculture (IMTA) system. We determined the lipid quality indices based on their fatty acid profiles and their bioactivities as putative antioxidant, anti-inflammatory and antiproliferative agents. The results reveal to be species-specific, namely U. rigida displayed the lowest atherogenicity and thrombogenicity indices. Palmaria palmata and F. vesiculosus lipid extracts displayed the lowest inhibitory concentration in the free radical scavenging antioxidant assays. Ulva rigida, C. tomentosum, P. palmata and P. dioica inhibited COX-2 activity by up to 80%, while P. dioica and P. palmata extracts showed the highest cytotoxic potential in the MDA-MB-231 breast cancer cells. This work enhances the valorization of macroalgae as functional foods and promising ingredients for sustainable and healthy diets and fosters new applications of high-valued algal biomass, in a species-specific context.
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spelling pubmed-75044982020-09-24 Valuing Bioactive Lipids from Green, Red and Brown Macroalgae from Aquaculture, to Foster Functionality and Biotechnological Applications Lopes, Diana Melo, Tânia Rey, Felisa Meneses, Joana Monteiro, Fátima Liliana Helguero, Luisa A. Abreu, Maria Helena Lillebø, Ana Isabel Calado, Ricardo Domingues, Maria Rosário Molecules Article Marine edible macroalgae have functional proprieties that might improve human health and wellbeing. Lipids represent a minor fraction of macroalgae, yet with major interest as main carriers of omega 3 polyunsaturated fatty acids and intrinsic bioactive properties. In this study, we used lipid extracts from the green macroalgae Ulva rigida and Codium tomentosum; the red Gracilaria gracilis, Palmaria palmata and Porphyra dioica; and the brown Fucus vesiculosus, produced in a land-based integrated multitrophic aquaculture (IMTA) system. We determined the lipid quality indices based on their fatty acid profiles and their bioactivities as putative antioxidant, anti-inflammatory and antiproliferative agents. The results reveal to be species-specific, namely U. rigida displayed the lowest atherogenicity and thrombogenicity indices. Palmaria palmata and F. vesiculosus lipid extracts displayed the lowest inhibitory concentration in the free radical scavenging antioxidant assays. Ulva rigida, C. tomentosum, P. palmata and P. dioica inhibited COX-2 activity by up to 80%, while P. dioica and P. palmata extracts showed the highest cytotoxic potential in the MDA-MB-231 breast cancer cells. This work enhances the valorization of macroalgae as functional foods and promising ingredients for sustainable and healthy diets and fosters new applications of high-valued algal biomass, in a species-specific context. MDPI 2020-08-26 /pmc/articles/PMC7504498/ /pubmed/32858862 http://dx.doi.org/10.3390/molecules25173883 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Lopes, Diana
Melo, Tânia
Rey, Felisa
Meneses, Joana
Monteiro, Fátima Liliana
Helguero, Luisa A.
Abreu, Maria Helena
Lillebø, Ana Isabel
Calado, Ricardo
Domingues, Maria Rosário
Valuing Bioactive Lipids from Green, Red and Brown Macroalgae from Aquaculture, to Foster Functionality and Biotechnological Applications
title Valuing Bioactive Lipids from Green, Red and Brown Macroalgae from Aquaculture, to Foster Functionality and Biotechnological Applications
title_full Valuing Bioactive Lipids from Green, Red and Brown Macroalgae from Aquaculture, to Foster Functionality and Biotechnological Applications
title_fullStr Valuing Bioactive Lipids from Green, Red and Brown Macroalgae from Aquaculture, to Foster Functionality and Biotechnological Applications
title_full_unstemmed Valuing Bioactive Lipids from Green, Red and Brown Macroalgae from Aquaculture, to Foster Functionality and Biotechnological Applications
title_short Valuing Bioactive Lipids from Green, Red and Brown Macroalgae from Aquaculture, to Foster Functionality and Biotechnological Applications
title_sort valuing bioactive lipids from green, red and brown macroalgae from aquaculture, to foster functionality and biotechnological applications
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7504498/
https://www.ncbi.nlm.nih.gov/pubmed/32858862
http://dx.doi.org/10.3390/molecules25173883
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