Krill Oil Attenuates Cognitive Impairment by the Regulation of Oxidative Stress and Neuronal Apoptosis in an Amyloid β-Induced Alzheimer’s Disease Mouse Model
In the present study, we investigated the cognitive improvement effects and its mechanisms of krill oil (KO) in Aβ(25–35)-induced Alzheimer’s disease (AD) mouse model. The Aβ(25–35)-injected AD mouse showed memory and cognitive impairment in the behavior tests. However, the administration of KO impr...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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MDPI
2020
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7504506/ https://www.ncbi.nlm.nih.gov/pubmed/32872354 http://dx.doi.org/10.3390/molecules25173942 |
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author | Kim, Ji Hyun Meng, Hui Wen He, Mei Tong Choi, Ji Myung Lee, Dongjun Cho, Eun Ju |
author_facet | Kim, Ji Hyun Meng, Hui Wen He, Mei Tong Choi, Ji Myung Lee, Dongjun Cho, Eun Ju |
author_sort | Kim, Ji Hyun |
collection | PubMed |
description | In the present study, we investigated the cognitive improvement effects and its mechanisms of krill oil (KO) in Aβ(25–35)-induced Alzheimer’s disease (AD) mouse model. The Aβ(25–35)-injected AD mouse showed memory and cognitive impairment in the behavior tests. However, the administration of KO improved novel object recognition ability and passive avoidance ability compared with Aβ(25–35)-injected control mice in behavior tests. In addition, KO-administered mice showed shorter latency to find the hidden platform in a Morris water maze test, indicating that KO improved learning and memory abilities. To evaluate the cognitive improvement mechanisms of KO, we measured the oxidative stress-related biomarkers and apoptosis-related protein expressions in the brain. The administration of KO inhibited oxidative stress-related biomarkers such as reactive oxygen species, malondialdehyde, and nitric oxide compared with AD control mice induced by Aβ(25–35). In addition, KO-administered mice showed down-regulation of Bax/Bcl-2 ratio in the brain. Therefore, this study indicated that KO-administered mice improved cognitive function against Aβ(25–35) by attenuations of neuronal oxidative stress and neuronal apoptosis. It suggests that KO might be a potential agent for prevention and treatment of AD. |
format | Online Article Text |
id | pubmed-7504506 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-75045062020-09-24 Krill Oil Attenuates Cognitive Impairment by the Regulation of Oxidative Stress and Neuronal Apoptosis in an Amyloid β-Induced Alzheimer’s Disease Mouse Model Kim, Ji Hyun Meng, Hui Wen He, Mei Tong Choi, Ji Myung Lee, Dongjun Cho, Eun Ju Molecules Article In the present study, we investigated the cognitive improvement effects and its mechanisms of krill oil (KO) in Aβ(25–35)-induced Alzheimer’s disease (AD) mouse model. The Aβ(25–35)-injected AD mouse showed memory and cognitive impairment in the behavior tests. However, the administration of KO improved novel object recognition ability and passive avoidance ability compared with Aβ(25–35)-injected control mice in behavior tests. In addition, KO-administered mice showed shorter latency to find the hidden platform in a Morris water maze test, indicating that KO improved learning and memory abilities. To evaluate the cognitive improvement mechanisms of KO, we measured the oxidative stress-related biomarkers and apoptosis-related protein expressions in the brain. The administration of KO inhibited oxidative stress-related biomarkers such as reactive oxygen species, malondialdehyde, and nitric oxide compared with AD control mice induced by Aβ(25–35). In addition, KO-administered mice showed down-regulation of Bax/Bcl-2 ratio in the brain. Therefore, this study indicated that KO-administered mice improved cognitive function against Aβ(25–35) by attenuations of neuronal oxidative stress and neuronal apoptosis. It suggests that KO might be a potential agent for prevention and treatment of AD. MDPI 2020-08-28 /pmc/articles/PMC7504506/ /pubmed/32872354 http://dx.doi.org/10.3390/molecules25173942 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Kim, Ji Hyun Meng, Hui Wen He, Mei Tong Choi, Ji Myung Lee, Dongjun Cho, Eun Ju Krill Oil Attenuates Cognitive Impairment by the Regulation of Oxidative Stress and Neuronal Apoptosis in an Amyloid β-Induced Alzheimer’s Disease Mouse Model |
title | Krill Oil Attenuates Cognitive Impairment by the Regulation of Oxidative Stress and Neuronal Apoptosis in an Amyloid β-Induced Alzheimer’s Disease Mouse Model |
title_full | Krill Oil Attenuates Cognitive Impairment by the Regulation of Oxidative Stress and Neuronal Apoptosis in an Amyloid β-Induced Alzheimer’s Disease Mouse Model |
title_fullStr | Krill Oil Attenuates Cognitive Impairment by the Regulation of Oxidative Stress and Neuronal Apoptosis in an Amyloid β-Induced Alzheimer’s Disease Mouse Model |
title_full_unstemmed | Krill Oil Attenuates Cognitive Impairment by the Regulation of Oxidative Stress and Neuronal Apoptosis in an Amyloid β-Induced Alzheimer’s Disease Mouse Model |
title_short | Krill Oil Attenuates Cognitive Impairment by the Regulation of Oxidative Stress and Neuronal Apoptosis in an Amyloid β-Induced Alzheimer’s Disease Mouse Model |
title_sort | krill oil attenuates cognitive impairment by the regulation of oxidative stress and neuronal apoptosis in an amyloid β-induced alzheimer’s disease mouse model |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7504506/ https://www.ncbi.nlm.nih.gov/pubmed/32872354 http://dx.doi.org/10.3390/molecules25173942 |
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