Exploring the regulatory roles of circular RNAs in Alzheimer’s disease

Circular RNAs (circRNAs) are a type of covalently closed, single-stranded circular noncoding RNA that can affect the expression of many protein-coding genes. Growing evidence has shown that circRNAs play critical roles in Alzheimer’s disease (AD) and may have therapeutic potentials for this disease....

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Autores principales: Zhang, Yuan, Zhao, Yanfang, Liu, Ying, Wang, Man, Yu, Wanpeng, Zhang, Lei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7504624/
https://www.ncbi.nlm.nih.gov/pubmed/32951610
http://dx.doi.org/10.1186/s40035-020-00216-z
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author Zhang, Yuan
Zhao, Yanfang
Liu, Ying
Wang, Man
Yu, Wanpeng
Zhang, Lei
author_facet Zhang, Yuan
Zhao, Yanfang
Liu, Ying
Wang, Man
Yu, Wanpeng
Zhang, Lei
author_sort Zhang, Yuan
collection PubMed
description Circular RNAs (circRNAs) are a type of covalently closed, single-stranded circular noncoding RNA that can affect the expression of many protein-coding genes. Growing evidence has shown that circRNAs play critical roles in Alzheimer’s disease (AD) and may have therapeutic potentials for this disease. CircRNAs play regulatory roles in neural functions and neurological disorders through diverse mechanisms, including acting as microRNA sponges or interacting with proteins to regulate selective splicing or transcription, as well as through epigenetic modification. In this review, we discuss the biogenesis and functions of circRNAs and the research progress on circRNAs in AD to advance the understanding of how circRNAs contribute to this neurological disorder.
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spelling pubmed-75046242020-09-23 Exploring the regulatory roles of circular RNAs in Alzheimer’s disease Zhang, Yuan Zhao, Yanfang Liu, Ying Wang, Man Yu, Wanpeng Zhang, Lei Transl Neurodegener Review Circular RNAs (circRNAs) are a type of covalently closed, single-stranded circular noncoding RNA that can affect the expression of many protein-coding genes. Growing evidence has shown that circRNAs play critical roles in Alzheimer’s disease (AD) and may have therapeutic potentials for this disease. CircRNAs play regulatory roles in neural functions and neurological disorders through diverse mechanisms, including acting as microRNA sponges or interacting with proteins to regulate selective splicing or transcription, as well as through epigenetic modification. In this review, we discuss the biogenesis and functions of circRNAs and the research progress on circRNAs in AD to advance the understanding of how circRNAs contribute to this neurological disorder. BioMed Central 2020-09-21 /pmc/articles/PMC7504624/ /pubmed/32951610 http://dx.doi.org/10.1186/s40035-020-00216-z Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Zhang, Yuan
Zhao, Yanfang
Liu, Ying
Wang, Man
Yu, Wanpeng
Zhang, Lei
Exploring the regulatory roles of circular RNAs in Alzheimer’s disease
title Exploring the regulatory roles of circular RNAs in Alzheimer’s disease
title_full Exploring the regulatory roles of circular RNAs in Alzheimer’s disease
title_fullStr Exploring the regulatory roles of circular RNAs in Alzheimer’s disease
title_full_unstemmed Exploring the regulatory roles of circular RNAs in Alzheimer’s disease
title_short Exploring the regulatory roles of circular RNAs in Alzheimer’s disease
title_sort exploring the regulatory roles of circular rnas in alzheimer’s disease
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7504624/
https://www.ncbi.nlm.nih.gov/pubmed/32951610
http://dx.doi.org/10.1186/s40035-020-00216-z
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