Mechanistic Insights into the Chaperoning of Human Lysosomal-Galactosidase Activity: Highly Functionalized Aminocyclopentanes and C-5a-Substituted Derivatives of 4-epi-Isofagomine

Glycosidase inhibitors have shown great potential as pharmacological chaperones for lysosomal storage diseases. In light of this, a series of new cyclopentanoid β-galactosidase inhibitors were prepared and their inhibitory and pharmacological chaperoning activities determined and compared with those...

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Detalles Bibliográficos
Autores principales: Weber, Patrick, Thonhofer, Martin, Averill, Summer, Davies, Gideon J., Santana, Andres Gonzalez, Müller, Philipp, Nasseri, Seyed A., Offen, Wendy A., Pabst, Bettina M., Paschke, Eduard, Schalli, Michael, Torvisco, Ana, Tschernutter, Marion, Tysoe, Christina, Windischhofer, Werner, Withers, Stephen G., Wolfsgruber, Andreas, Wrodnigg, Tanja M., Stütz, Arnold E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7504770/
https://www.ncbi.nlm.nih.gov/pubmed/32899288
http://dx.doi.org/10.3390/molecules25174025

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