Review of the Synthesis and Anticancer Properties of Pyrazolo[4,3-e][1,2,4]triazine Derivatives

This review focuses on the cytotoxic effect of new synthetic pyrazolo[4,3-e][1,2,4]triazine derivatives against different tumor cell lines. Some annulated pyrazolotriazines i.e., pyrazolo[4,3-e][1,2,4]triazolo[4,3-b][1,2,4]triazines and pyrazolo[4,3-e]tetrazolo[1,5-b][1,2,4]triazine demonstrated sig...

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Detalles Bibliográficos
Autores principales: Bernat, Zofia, Szymanowska, Anna, Kciuk, Mateusz, Kotwica-Mojzych, Katarzyna, Mojzych, Mariusz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7504782/
https://www.ncbi.nlm.nih.gov/pubmed/32872493
http://dx.doi.org/10.3390/molecules25173948
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author Bernat, Zofia
Szymanowska, Anna
Kciuk, Mateusz
Kotwica-Mojzych, Katarzyna
Mojzych, Mariusz
author_facet Bernat, Zofia
Szymanowska, Anna
Kciuk, Mateusz
Kotwica-Mojzych, Katarzyna
Mojzych, Mariusz
author_sort Bernat, Zofia
collection PubMed
description This review focuses on the cytotoxic effect of new synthetic pyrazolo[4,3-e][1,2,4]triazine derivatives against different tumor cell lines. Some annulated pyrazolotriazines i.e., pyrazolo[4,3-e][1,2,4]triazolo[4,3-b][1,2,4]triazines and pyrazolo[4,3-e]tetrazolo[1,5-b][1,2,4]triazine demonstrated significant broad cytotoxic activity in micromolar range concentration, which could have excellent potential to be new candidate therapeutic agents in cancer chemotherapy.
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spelling pubmed-75047822020-09-26 Review of the Synthesis and Anticancer Properties of Pyrazolo[4,3-e][1,2,4]triazine Derivatives Bernat, Zofia Szymanowska, Anna Kciuk, Mateusz Kotwica-Mojzych, Katarzyna Mojzych, Mariusz Molecules Review This review focuses on the cytotoxic effect of new synthetic pyrazolo[4,3-e][1,2,4]triazine derivatives against different tumor cell lines. Some annulated pyrazolotriazines i.e., pyrazolo[4,3-e][1,2,4]triazolo[4,3-b][1,2,4]triazines and pyrazolo[4,3-e]tetrazolo[1,5-b][1,2,4]triazine demonstrated significant broad cytotoxic activity in micromolar range concentration, which could have excellent potential to be new candidate therapeutic agents in cancer chemotherapy. MDPI 2020-08-29 /pmc/articles/PMC7504782/ /pubmed/32872493 http://dx.doi.org/10.3390/molecules25173948 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Bernat, Zofia
Szymanowska, Anna
Kciuk, Mateusz
Kotwica-Mojzych, Katarzyna
Mojzych, Mariusz
Review of the Synthesis and Anticancer Properties of Pyrazolo[4,3-e][1,2,4]triazine Derivatives
title Review of the Synthesis and Anticancer Properties of Pyrazolo[4,3-e][1,2,4]triazine Derivatives
title_full Review of the Synthesis and Anticancer Properties of Pyrazolo[4,3-e][1,2,4]triazine Derivatives
title_fullStr Review of the Synthesis and Anticancer Properties of Pyrazolo[4,3-e][1,2,4]triazine Derivatives
title_full_unstemmed Review of the Synthesis and Anticancer Properties of Pyrazolo[4,3-e][1,2,4]triazine Derivatives
title_short Review of the Synthesis and Anticancer Properties of Pyrazolo[4,3-e][1,2,4]triazine Derivatives
title_sort review of the synthesis and anticancer properties of pyrazolo[4,3-e][1,2,4]triazine derivatives
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7504782/
https://www.ncbi.nlm.nih.gov/pubmed/32872493
http://dx.doi.org/10.3390/molecules25173948
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