Analysis of Taste Sensitivities in App Knock-In Mouse Model of Alzheimer’s Disease

BACKGROUND: Some studies have reported a decline in taste sensitivities in patients with Alzheimer’s disease. However, the detail remains unknown. OBJECTIVE: We investigated the effect of cognitive impairment on taste sensitivity using an App knock-in mouse model of Alzheimer’s disease. METHODS: Beh...

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Detalles Bibliográficos
Autores principales: Narukawa, Masataka, Takahashi, Suzuka, Saito, Takashi, Saido, Takaomi C., Misaka, Takumi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: IOS Press 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7504995/
https://www.ncbi.nlm.nih.gov/pubmed/32568206
http://dx.doi.org/10.3233/JAD-200284
Descripción
Sumario:BACKGROUND: Some studies have reported a decline in taste sensitivities in patients with Alzheimer’s disease. However, the detail remains unknown. OBJECTIVE: We investigated the effect of cognitive impairment on taste sensitivity using an App knock-in mouse model of Alzheimer’s disease. METHODS: Behavioral assays, a brief access test, and a 48 h two-bottle preference test, to assess taste sensitivities were started from 12 months of age in mice that were confirmed to have impaired cognition. RESULTS: In the assays, there was no significant difference in taste sensitivities between wild type and App knock-in mice. Additionally, no apparent difference was observed in the expression of taste markers in their taste bud cells. CONCLUSION: We concluded that cognitive impairment might not greatly affect taste sensitivity.

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