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Intranasal Dantrolene as a Disease-Modifying Drug in Alzheimer 5XFAD Mice

BACKGROUND/OBJECTIVE: This study compares the effectiveness and safety of intranasal versus subcutaneous administration of dantrolene in 5XFAD Alzheimer’s disease (AD) mice. METHODS: 5XFAD and wild type (WT) B6SJLF1/J mice were treated with intranasal or subcutaneous dantrolene (5 mg/kg, 3×/wk), or...

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Detalles Bibliográficos
Autores principales:	Shi, Yun, Zhang, Lei, Gao, Xue, Zhang, Jing, Ben Abou, Matan, Liang, Ge, Meng, Qingcheng, Hepner, Adrian, Eckenhoff, Maryellen F., Wei, Huafeng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	IOS Press 2020
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7505009/ https://www.ncbi.nlm.nih.gov/pubmed/32623395 http://dx.doi.org/10.3233/JAD-200227

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