Cargando…
The MOMENTUM Study: An International Registry for the Evidence-Based Introduction of MR-Guided Adaptive Therapy
Purpose: MR-guided Radiation Therapy (MRgRT) allows for high-precision radiotherapy under real-time MR visualization. This enables margin reduction and subsequent dose escalation which may lead to higher tumor control and less toxicity. The Unity MR-linac (Elekta AB, Stockholm, Sweden) integrates a...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7505056/ https://www.ncbi.nlm.nih.gov/pubmed/33014774 http://dx.doi.org/10.3389/fonc.2020.01328 |
_version_ | 1783584741336809472 |
---|---|
author | de Mol van Otterloo, Sophie R. Christodouleas, John P. Blezer, Erwin L. A. Akhiat, Hafid Brown, Kevin Choudhury, Ananya Eggert, Dave Erickson, Beth A. Faivre-Finn, Corinne Fuller, Clifton D. Goldwein, Joel Hafeez, Shaista Hall, Emma Harrington, Kevin J. van der Heide, Uulke A. Huddart, Robert A. Intven, Martijn P. W. Kirby, Anna M. Lalondrelle, Susan McCann, Claire Minsky, Bruce D. Mook, Stella Nowee, Marlies E. Oelfke, Uwe Orrling, Kristina Sahgal, Arjun Sarmiento, Jeffrey G. Schultz, Christopher J. Tersteeg, Robbert J. H. A. Tijssen, Rob H. N. Tree, Alison C. van Triest, Baukelien Hall, William A. Verkooijen, Helena M. |
author_facet | de Mol van Otterloo, Sophie R. Christodouleas, John P. Blezer, Erwin L. A. Akhiat, Hafid Brown, Kevin Choudhury, Ananya Eggert, Dave Erickson, Beth A. Faivre-Finn, Corinne Fuller, Clifton D. Goldwein, Joel Hafeez, Shaista Hall, Emma Harrington, Kevin J. van der Heide, Uulke A. Huddart, Robert A. Intven, Martijn P. W. Kirby, Anna M. Lalondrelle, Susan McCann, Claire Minsky, Bruce D. Mook, Stella Nowee, Marlies E. Oelfke, Uwe Orrling, Kristina Sahgal, Arjun Sarmiento, Jeffrey G. Schultz, Christopher J. Tersteeg, Robbert J. H. A. Tijssen, Rob H. N. Tree, Alison C. van Triest, Baukelien Hall, William A. Verkooijen, Helena M. |
author_sort | de Mol van Otterloo, Sophie R. |
collection | PubMed |
description | Purpose: MR-guided Radiation Therapy (MRgRT) allows for high-precision radiotherapy under real-time MR visualization. This enables margin reduction and subsequent dose escalation which may lead to higher tumor control and less toxicity. The Unity MR-linac (Elekta AB, Stockholm, Sweden) integrates a linear accelerator with a 1.5T diagnostic quality MRI and an online adaptive workflow. A prospective international registry was established to facilitate the evidence-based implementation of the Unity MR-linac into clinical practice, to systemically evaluate long-term outcomes, and to aid further technical development of MR-linac-based MRgRT. Methods and Results: In February 2019, the Multi-OutcoMe EvaluatioN of radiation Therapy Using the MR-linac study (MOMENTUM) started within the MR-linac Consortium. The MOMENTUM study is an international academic-industrial partnership between several hospitals and industry partner Elekta. All patients treated on the MR-linac are eligible for inclusion in MOMENTUM. For participants, we collect clinical patient data (e.g., patient, tumor, and treatment characteristics) and technical patient data which is defined as information generated on the MR-linac during treatment. The data are captured, pseudonymized, and stored in an international registry at set time intervals up to two years after treatment. Patients can choose to provide patient-reported outcomes and consent to additional MRI scans acquired on the MR-linac. This registry will serve as a data platform that supports multicenter research investigating the MR-linac. Rules and regulations on data sharing, data access, and intellectual property rights are summarized in an academic-industrial collaboration agreement. Data access rules ensure secure data handling and research integrity for investigators and institutions. Separate data access rules exist for academic and industry partners. This study is registered at ClinicalTrials.gov with ID: NCT04075305 (https://clinicaltrials.gov/ct2/show/NCT04075305). Conclusion: The multi-institutional MOMENTUM study has been set up to collect clinical and technical patient data to advance technical development, and facilitate evidenced-based implementation of MR-linac technology with the ultimate purpose to improve tumor control, survival, and quality of life of patients with cancer. |
format | Online Article Text |
id | pubmed-7505056 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-75050562020-10-02 The MOMENTUM Study: An International Registry for the Evidence-Based Introduction of MR-Guided Adaptive Therapy de Mol van Otterloo, Sophie R. Christodouleas, John P. Blezer, Erwin L. A. Akhiat, Hafid Brown, Kevin Choudhury, Ananya Eggert, Dave Erickson, Beth A. Faivre-Finn, Corinne Fuller, Clifton D. Goldwein, Joel Hafeez, Shaista Hall, Emma Harrington, Kevin J. van der Heide, Uulke A. Huddart, Robert A. Intven, Martijn P. W. Kirby, Anna M. Lalondrelle, Susan McCann, Claire Minsky, Bruce D. Mook, Stella Nowee, Marlies E. Oelfke, Uwe Orrling, Kristina Sahgal, Arjun Sarmiento, Jeffrey G. Schultz, Christopher J. Tersteeg, Robbert J. H. A. Tijssen, Rob H. N. Tree, Alison C. van Triest, Baukelien Hall, William A. Verkooijen, Helena M. Front Oncol Oncology Purpose: MR-guided Radiation Therapy (MRgRT) allows for high-precision radiotherapy under real-time MR visualization. This enables margin reduction and subsequent dose escalation which may lead to higher tumor control and less toxicity. The Unity MR-linac (Elekta AB, Stockholm, Sweden) integrates a linear accelerator with a 1.5T diagnostic quality MRI and an online adaptive workflow. A prospective international registry was established to facilitate the evidence-based implementation of the Unity MR-linac into clinical practice, to systemically evaluate long-term outcomes, and to aid further technical development of MR-linac-based MRgRT. Methods and Results: In February 2019, the Multi-OutcoMe EvaluatioN of radiation Therapy Using the MR-linac study (MOMENTUM) started within the MR-linac Consortium. The MOMENTUM study is an international academic-industrial partnership between several hospitals and industry partner Elekta. All patients treated on the MR-linac are eligible for inclusion in MOMENTUM. For participants, we collect clinical patient data (e.g., patient, tumor, and treatment characteristics) and technical patient data which is defined as information generated on the MR-linac during treatment. The data are captured, pseudonymized, and stored in an international registry at set time intervals up to two years after treatment. Patients can choose to provide patient-reported outcomes and consent to additional MRI scans acquired on the MR-linac. This registry will serve as a data platform that supports multicenter research investigating the MR-linac. Rules and regulations on data sharing, data access, and intellectual property rights are summarized in an academic-industrial collaboration agreement. Data access rules ensure secure data handling and research integrity for investigators and institutions. Separate data access rules exist for academic and industry partners. This study is registered at ClinicalTrials.gov with ID: NCT04075305 (https://clinicaltrials.gov/ct2/show/NCT04075305). Conclusion: The multi-institutional MOMENTUM study has been set up to collect clinical and technical patient data to advance technical development, and facilitate evidenced-based implementation of MR-linac technology with the ultimate purpose to improve tumor control, survival, and quality of life of patients with cancer. Frontiers Media S.A. 2020-09-07 /pmc/articles/PMC7505056/ /pubmed/33014774 http://dx.doi.org/10.3389/fonc.2020.01328 Text en Copyright © 2020 de Mol van Otterloo, Christodouleas, Blezer, Akhiat, Brown, Choudhury, Eggert, Erickson, Faivre-Finn, Fuller, Goldwein, Hafeez, Hall, Harrington, van der Heide, Huddart, Intven, Kirby, Lalondrelle, McCann, Minsky, Mook, Nowee, Oelfke, Orrling, Sahgal, Sarmiento, Schultz, Tersteeg, Tijssen, Tree, van Triest, Hall and Verkooijen. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Oncology de Mol van Otterloo, Sophie R. Christodouleas, John P. Blezer, Erwin L. A. Akhiat, Hafid Brown, Kevin Choudhury, Ananya Eggert, Dave Erickson, Beth A. Faivre-Finn, Corinne Fuller, Clifton D. Goldwein, Joel Hafeez, Shaista Hall, Emma Harrington, Kevin J. van der Heide, Uulke A. Huddart, Robert A. Intven, Martijn P. W. Kirby, Anna M. Lalondrelle, Susan McCann, Claire Minsky, Bruce D. Mook, Stella Nowee, Marlies E. Oelfke, Uwe Orrling, Kristina Sahgal, Arjun Sarmiento, Jeffrey G. Schultz, Christopher J. Tersteeg, Robbert J. H. A. Tijssen, Rob H. N. Tree, Alison C. van Triest, Baukelien Hall, William A. Verkooijen, Helena M. The MOMENTUM Study: An International Registry for the Evidence-Based Introduction of MR-Guided Adaptive Therapy |
title | The MOMENTUM Study: An International Registry for the Evidence-Based Introduction of MR-Guided Adaptive Therapy |
title_full | The MOMENTUM Study: An International Registry for the Evidence-Based Introduction of MR-Guided Adaptive Therapy |
title_fullStr | The MOMENTUM Study: An International Registry for the Evidence-Based Introduction of MR-Guided Adaptive Therapy |
title_full_unstemmed | The MOMENTUM Study: An International Registry for the Evidence-Based Introduction of MR-Guided Adaptive Therapy |
title_short | The MOMENTUM Study: An International Registry for the Evidence-Based Introduction of MR-Guided Adaptive Therapy |
title_sort | momentum study: an international registry for the evidence-based introduction of mr-guided adaptive therapy |
topic | Oncology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7505056/ https://www.ncbi.nlm.nih.gov/pubmed/33014774 http://dx.doi.org/10.3389/fonc.2020.01328 |
work_keys_str_mv | AT demolvanotterloosophier themomentumstudyaninternationalregistryfortheevidencebasedintroductionofmrguidedadaptivetherapy AT christodouleasjohnp themomentumstudyaninternationalregistryfortheevidencebasedintroductionofmrguidedadaptivetherapy AT blezererwinla themomentumstudyaninternationalregistryfortheevidencebasedintroductionofmrguidedadaptivetherapy AT akhiathafid themomentumstudyaninternationalregistryfortheevidencebasedintroductionofmrguidedadaptivetherapy AT brownkevin themomentumstudyaninternationalregistryfortheevidencebasedintroductionofmrguidedadaptivetherapy AT choudhuryananya themomentumstudyaninternationalregistryfortheevidencebasedintroductionofmrguidedadaptivetherapy AT eggertdave themomentumstudyaninternationalregistryfortheevidencebasedintroductionofmrguidedadaptivetherapy AT ericksonbetha themomentumstudyaninternationalregistryfortheevidencebasedintroductionofmrguidedadaptivetherapy AT faivrefinncorinne themomentumstudyaninternationalregistryfortheevidencebasedintroductionofmrguidedadaptivetherapy AT fullercliftond themomentumstudyaninternationalregistryfortheevidencebasedintroductionofmrguidedadaptivetherapy AT goldweinjoel themomentumstudyaninternationalregistryfortheevidencebasedintroductionofmrguidedadaptivetherapy AT hafeezshaista themomentumstudyaninternationalregistryfortheevidencebasedintroductionofmrguidedadaptivetherapy AT hallemma themomentumstudyaninternationalregistryfortheevidencebasedintroductionofmrguidedadaptivetherapy AT harringtonkevinj themomentumstudyaninternationalregistryfortheevidencebasedintroductionofmrguidedadaptivetherapy AT vanderheideuulkea themomentumstudyaninternationalregistryfortheevidencebasedintroductionofmrguidedadaptivetherapy AT huddartroberta themomentumstudyaninternationalregistryfortheevidencebasedintroductionofmrguidedadaptivetherapy AT intvenmartijnpw themomentumstudyaninternationalregistryfortheevidencebasedintroductionofmrguidedadaptivetherapy AT kirbyannam themomentumstudyaninternationalregistryfortheevidencebasedintroductionofmrguidedadaptivetherapy AT lalondrellesusan themomentumstudyaninternationalregistryfortheevidencebasedintroductionofmrguidedadaptivetherapy AT mccannclaire themomentumstudyaninternationalregistryfortheevidencebasedintroductionofmrguidedadaptivetherapy AT minskybruced themomentumstudyaninternationalregistryfortheevidencebasedintroductionofmrguidedadaptivetherapy AT mookstella themomentumstudyaninternationalregistryfortheevidencebasedintroductionofmrguidedadaptivetherapy AT noweemarliese themomentumstudyaninternationalregistryfortheevidencebasedintroductionofmrguidedadaptivetherapy AT oelfkeuwe themomentumstudyaninternationalregistryfortheevidencebasedintroductionofmrguidedadaptivetherapy AT orrlingkristina themomentumstudyaninternationalregistryfortheevidencebasedintroductionofmrguidedadaptivetherapy AT sahgalarjun themomentumstudyaninternationalregistryfortheevidencebasedintroductionofmrguidedadaptivetherapy AT sarmientojeffreyg themomentumstudyaninternationalregistryfortheevidencebasedintroductionofmrguidedadaptivetherapy AT schultzchristopherj themomentumstudyaninternationalregistryfortheevidencebasedintroductionofmrguidedadaptivetherapy AT tersteegrobbertjha themomentumstudyaninternationalregistryfortheevidencebasedintroductionofmrguidedadaptivetherapy AT tijssenrobhn themomentumstudyaninternationalregistryfortheevidencebasedintroductionofmrguidedadaptivetherapy AT treealisonc themomentumstudyaninternationalregistryfortheevidencebasedintroductionofmrguidedadaptivetherapy AT vantriestbaukelien themomentumstudyaninternationalregistryfortheevidencebasedintroductionofmrguidedadaptivetherapy AT hallwilliama themomentumstudyaninternationalregistryfortheevidencebasedintroductionofmrguidedadaptivetherapy AT verkooijenhelenam themomentumstudyaninternationalregistryfortheevidencebasedintroductionofmrguidedadaptivetherapy AT demolvanotterloosophier momentumstudyaninternationalregistryfortheevidencebasedintroductionofmrguidedadaptivetherapy AT christodouleasjohnp momentumstudyaninternationalregistryfortheevidencebasedintroductionofmrguidedadaptivetherapy AT blezererwinla momentumstudyaninternationalregistryfortheevidencebasedintroductionofmrguidedadaptivetherapy AT akhiathafid momentumstudyaninternationalregistryfortheevidencebasedintroductionofmrguidedadaptivetherapy AT brownkevin momentumstudyaninternationalregistryfortheevidencebasedintroductionofmrguidedadaptivetherapy AT choudhuryananya momentumstudyaninternationalregistryfortheevidencebasedintroductionofmrguidedadaptivetherapy AT eggertdave momentumstudyaninternationalregistryfortheevidencebasedintroductionofmrguidedadaptivetherapy AT ericksonbetha momentumstudyaninternationalregistryfortheevidencebasedintroductionofmrguidedadaptivetherapy AT faivrefinncorinne momentumstudyaninternationalregistryfortheevidencebasedintroductionofmrguidedadaptivetherapy AT fullercliftond momentumstudyaninternationalregistryfortheevidencebasedintroductionofmrguidedadaptivetherapy AT goldweinjoel momentumstudyaninternationalregistryfortheevidencebasedintroductionofmrguidedadaptivetherapy AT hafeezshaista momentumstudyaninternationalregistryfortheevidencebasedintroductionofmrguidedadaptivetherapy AT hallemma momentumstudyaninternationalregistryfortheevidencebasedintroductionofmrguidedadaptivetherapy AT harringtonkevinj momentumstudyaninternationalregistryfortheevidencebasedintroductionofmrguidedadaptivetherapy AT vanderheideuulkea momentumstudyaninternationalregistryfortheevidencebasedintroductionofmrguidedadaptivetherapy AT huddartroberta momentumstudyaninternationalregistryfortheevidencebasedintroductionofmrguidedadaptivetherapy AT intvenmartijnpw momentumstudyaninternationalregistryfortheevidencebasedintroductionofmrguidedadaptivetherapy AT kirbyannam momentumstudyaninternationalregistryfortheevidencebasedintroductionofmrguidedadaptivetherapy AT lalondrellesusan momentumstudyaninternationalregistryfortheevidencebasedintroductionofmrguidedadaptivetherapy AT mccannclaire momentumstudyaninternationalregistryfortheevidencebasedintroductionofmrguidedadaptivetherapy AT minskybruced momentumstudyaninternationalregistryfortheevidencebasedintroductionofmrguidedadaptivetherapy AT mookstella momentumstudyaninternationalregistryfortheevidencebasedintroductionofmrguidedadaptivetherapy AT noweemarliese momentumstudyaninternationalregistryfortheevidencebasedintroductionofmrguidedadaptivetherapy AT oelfkeuwe momentumstudyaninternationalregistryfortheevidencebasedintroductionofmrguidedadaptivetherapy AT orrlingkristina momentumstudyaninternationalregistryfortheevidencebasedintroductionofmrguidedadaptivetherapy AT sahgalarjun momentumstudyaninternationalregistryfortheevidencebasedintroductionofmrguidedadaptivetherapy AT sarmientojeffreyg momentumstudyaninternationalregistryfortheevidencebasedintroductionofmrguidedadaptivetherapy AT schultzchristopherj momentumstudyaninternationalregistryfortheevidencebasedintroductionofmrguidedadaptivetherapy AT tersteegrobbertjha momentumstudyaninternationalregistryfortheevidencebasedintroductionofmrguidedadaptivetherapy AT tijssenrobhn momentumstudyaninternationalregistryfortheevidencebasedintroductionofmrguidedadaptivetherapy AT treealisonc momentumstudyaninternationalregistryfortheevidencebasedintroductionofmrguidedadaptivetherapy AT vantriestbaukelien momentumstudyaninternationalregistryfortheevidencebasedintroductionofmrguidedadaptivetherapy AT hallwilliama momentumstudyaninternationalregistryfortheevidencebasedintroductionofmrguidedadaptivetherapy AT verkooijenhelenam momentumstudyaninternationalregistryfortheevidencebasedintroductionofmrguidedadaptivetherapy |