Molecular docking analysis of amyloid precursor protein with compounds from the Australian cowplant

Amyloid precursor protein is linked with Alzheimer's disease (AD). The Australian cowplant Gymnema sylvestre is known in Indian and Chinese medicine. Therefore, it is of interest to screen the Amyloid precursor protein with compounds from the Australian cowplant. We report five compounds (Gymne...

Descripción completa

Detalles Bibliográficos
Autores principales: Selvaraj, Jayaraman, Sardar, Hussain, Vishnupriya, Veeraraghavan, Balakrishna, Janardhana Papayya, Mohan, Surapaneni Krishna, Nivedha, Rajamanickam Pon, Vijayalakshmi, Periyasamy, Ponnulakshmi, Rajagopal
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Biomedical Informatics 2020
Materias:
Research-Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7505243/
https://www.ncbi.nlm.nih.gov/pubmed/32994682
http://dx.doi.org/10.6026/97320630016561
Descripción
Sumario:Amyloid precursor protein is linked with Alzheimer's disease (AD). The Australian cowplant Gymnema sylvestre is known in Indian and Chinese medicine. Therefore, it is of interest to screen the Amyloid precursor protein with compounds from the Australian cowplant. We report five compounds (Gymnemasaponin 5, Gymnemasin D, Gymnemoside A, Gymnemoside E, Gymnemoside F) derived from the Australian cowplant as the poteinal inhibitors of Amyloid precursor protein with optimal binding features for further consideration.

Ejemplares similares