Molecular docking analysis of amyloid precursor protein with compounds from the Australian cowplant

Amyloid precursor protein is linked with Alzheimer's disease (AD). The Australian cowplant Gymnema sylvestre is known in Indian and Chinese medicine. Therefore, it is of interest to screen the Amyloid precursor protein with compounds from the Australian cowplant. We report five compounds (Gymne...

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Autores principales: Selvaraj, Jayaraman, Sardar, Hussain, Vishnupriya, Veeraraghavan, Balakrishna, Janardhana Papayya, Mohan, Surapaneni Krishna, Nivedha, Rajamanickam Pon, Vijayalakshmi, Periyasamy, Ponnulakshmi, Rajagopal
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Biomedical Informatics 2020
Materias:
Research-Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7505243/
https://www.ncbi.nlm.nih.gov/pubmed/32994682
http://dx.doi.org/10.6026/97320630016561
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author Selvaraj, Jayaraman
Sardar, Hussain
Vishnupriya, Veeraraghavan
Balakrishna, Janardhana Papayya
Mohan, Surapaneni Krishna
Nivedha, Rajamanickam Pon
Vijayalakshmi, Periyasamy
Ponnulakshmi, Rajagopal
author_facet Selvaraj, Jayaraman
Sardar, Hussain
Vishnupriya, Veeraraghavan
Balakrishna, Janardhana Papayya
Mohan, Surapaneni Krishna
Nivedha, Rajamanickam Pon
Vijayalakshmi, Periyasamy
Ponnulakshmi, Rajagopal
author_sort Selvaraj, Jayaraman
collection PubMed
description Amyloid precursor protein is linked with Alzheimer's disease (AD). The Australian cowplant Gymnema sylvestre is known in Indian and Chinese medicine. Therefore, it is of interest to screen the Amyloid precursor protein with compounds from the Australian cowplant. We report five compounds (Gymnemasaponin 5, Gymnemasin D, Gymnemoside A, Gymnemoside E, Gymnemoside F) derived from the Australian cowplant as the poteinal inhibitors of Amyloid precursor protein with optimal binding features for further consideration.
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spelling pubmed-75052432020-09-28 Molecular docking analysis of amyloid precursor protein with compounds from the Australian cowplant Selvaraj, Jayaraman Sardar, Hussain Vishnupriya, Veeraraghavan Balakrishna, Janardhana Papayya Mohan, Surapaneni Krishna Nivedha, Rajamanickam Pon Vijayalakshmi, Periyasamy Ponnulakshmi, Rajagopal Bioinformation Research-Article Amyloid precursor protein is linked with Alzheimer's disease (AD). The Australian cowplant Gymnema sylvestre is known in Indian and Chinese medicine. Therefore, it is of interest to screen the Amyloid precursor protein with compounds from the Australian cowplant. We report five compounds (Gymnemasaponin 5, Gymnemasin D, Gymnemoside A, Gymnemoside E, Gymnemoside F) derived from the Australian cowplant as the poteinal inhibitors of Amyloid precursor protein with optimal binding features for further consideration. Biomedical Informatics 2020-07-31 /pmc/articles/PMC7505243/ /pubmed/32994682 http://dx.doi.org/10.6026/97320630016561 Text en © 2020 Biomedical Informatics http://creativecommons.org/licenses/by/3.0/ This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.
spellingShingle Research-Article
Selvaraj, Jayaraman
Sardar, Hussain
Vishnupriya, Veeraraghavan
Balakrishna, Janardhana Papayya
Mohan, Surapaneni Krishna
Nivedha, Rajamanickam Pon
Vijayalakshmi, Periyasamy
Ponnulakshmi, Rajagopal
Molecular docking analysis of amyloid precursor protein with compounds from the Australian cowplant
title Molecular docking analysis of amyloid precursor protein with compounds from the Australian cowplant
title_full Molecular docking analysis of amyloid precursor protein with compounds from the Australian cowplant
title_fullStr Molecular docking analysis of amyloid precursor protein with compounds from the Australian cowplant
title_full_unstemmed Molecular docking analysis of amyloid precursor protein with compounds from the Australian cowplant
title_short Molecular docking analysis of amyloid precursor protein with compounds from the Australian cowplant
title_sort molecular docking analysis of amyloid precursor protein with compounds from the australian cowplant
topic Research-Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7505243/
https://www.ncbi.nlm.nih.gov/pubmed/32994682
http://dx.doi.org/10.6026/97320630016561
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