Cargando…

Cribriform pattern does not have a significant impact in Gleason Score ≥7/ISUP Grade ≥2 prostate cancers submitted to radical prostatectomy

INTRODUCTION: The aim of this study was to correlate cribriform pattern (CP) with other parameters in a large prospective series of Gleason score ≥7/ISUP grade ≥2 prostate cancer (PC) cases undergoing radical prostatectomy (RP). METHODS: This is a prospective single-center study on 210 consecutive p...

Descripción completa

Detalles Bibliográficos
Autores principales: Flammia, Simone, Frisenda, Marco, Maggi, Martina, Magliocca, Fabio Massimo, Ciardi, Antonio, Panebianco, Valeria, De Berardinis, Ettore, Salciccia, Stefano, Di Pierro, Giovanni Battista, Gentilucci, Alessandro, Del Giudice, Francesco, Busetto, Gian Maria, Gallucci, Michele, Sciarra, Alessandro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7505347/
https://www.ncbi.nlm.nih.gov/pubmed/32957339
http://dx.doi.org/10.1097/MD.0000000000022156
Descripción
Sumario:INTRODUCTION: The aim of this study was to correlate cribriform pattern (CP) with other parameters in a large prospective series of Gleason score ≥7/ISUP grade ≥2 prostate cancer (PC) cases undergoing radical prostatectomy (RP). METHODS: This is a prospective single-center study on 210 consecutive patients. Gleason pattern 4 and individual tumor growth patterns determination were performed either in biopsy or in surgical specimens for all patients. RESULTS: At multiparametric magnetic resonance, a higher percentage of PI-RADS 5 was associated to CP (53.3% vs 17.7%, P = .038). CP was significantly and inversely (r = −0.261; P = .001) correlated with perineural invasion (PNI) but not with other pathological parameters. Kaplan-Meier analysis showed that mean biochemical (Bp) and radiological (Rp) progression-free survival were similar (Bp = χ(2) 0.906; P = .341; Rp = χ(2) 1.880; P = .170) independently to CP. In PNI positive cases, Bp-free survival was higher (χ(2) = 3.617; P = .057) in cases without CP. CONCLUSIONS: In a homogeneous population excluding ISUP 1 cases, CP showed limited prognostic value. We first described an association with PNI and a prognostic value influenced by PNI status.