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Adjuvanted HIV-1 vaccine promotes antibody-dependent phagocytic responses and protects against heterologous SHIV challenge

To augment HIV-1 pox-protein vaccine immunogenicity using a next generation adjuvant, a prime-boost strategy of recombinant modified vaccinia virus Ankara and multimeric Env gp145 was evaluated in macaques with either aluminum (alum) or a novel liposomal monophosphoryl lipid A (MPLA) formulation ads...

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Detalles Bibliográficos
Autores principales:	Om, Kier, Paquin-Proulx, Dominic, Montero, Maria, Peachman, Kristina, Shen, Xiaoying, Wieczorek, Lindsay, Beck, Zoltan, Weiner, Joshua A., Kim, Dohoon, Li, Yifan, Mdluli, Thembi, Shubin, Zhanna, Bryant, Christopher, Sharma, Vishakha, Tokarev, Andrey, Dawson, Peter, White, Yohann, Appelbe, Oliver, Klatt, Nichole R., Tovanabutra, Sodsai, Estes, Jacob D., Matyas, Gary R., Ferrari, Guido, Alving, Carl R., Tomaras, Georgia D., Ackerman, Margaret E., Michael, Nelson L., Robb, Merlin L., Polonis, Victoria, Rolland, Morgane, Eller, Michael A., Rao, Mangala, Bolton, Diane L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2020
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7505435/ https://www.ncbi.nlm.nih.gov/pubmed/32881968 http://dx.doi.org/10.1371/journal.ppat.1008764

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