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Evaluation of ocular involvement in patients with Hansen’s disease

Hansen’s disease (HD) belongs to the group of neglected diseases and can cause physical deformities and disabilities, in addition to leading to social discrimination. Ocular involvement in HD is estimated at 70–75% worldwide. About 10–50% suffer from severe ocular symptoms and loss of vision occurs...

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Autores principales: Pavezzi, Priscila Daiane, do Prado, Rodrigo Bueno, Boin Filho, Plinio Ângelo, Gon, Airton dos Santos, Tuma, Bruna, Fornazieri, Marco Aurelio, Scalone, Fabiana de Mari, Alves, Luciana Rigolin Mazoni, Montero, Ricardo Hirayama, Casella, Antonio Marcelo Barbante
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7505469/
https://www.ncbi.nlm.nih.gov/pubmed/32956360
http://dx.doi.org/10.1371/journal.pntd.0008585
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author Pavezzi, Priscila Daiane
do Prado, Rodrigo Bueno
Boin Filho, Plinio Ângelo
Gon, Airton dos Santos
Tuma, Bruna
Fornazieri, Marco Aurelio
Scalone, Fabiana de Mari
Alves, Luciana Rigolin Mazoni
Montero, Ricardo Hirayama
Casella, Antonio Marcelo Barbante
author_facet Pavezzi, Priscila Daiane
do Prado, Rodrigo Bueno
Boin Filho, Plinio Ângelo
Gon, Airton dos Santos
Tuma, Bruna
Fornazieri, Marco Aurelio
Scalone, Fabiana de Mari
Alves, Luciana Rigolin Mazoni
Montero, Ricardo Hirayama
Casella, Antonio Marcelo Barbante
author_sort Pavezzi, Priscila Daiane
collection PubMed
description Hansen’s disease (HD) belongs to the group of neglected diseases and can cause physical deformities and disabilities, in addition to leading to social discrimination. Ocular involvement in HD is estimated at 70–75% worldwide. About 10–50% suffer from severe ocular symptoms and loss of vision occurs in approximately 5% of cases. Ocular changes may persist or worsen even after patients are considered cured and it is necessary to better understand these conditions in order to determine the need for additional public policies. The objective of this study was to identify the prevalence of ocular involvement in patients with HD at two specialist referral centers for treatment of the disease. A cross-sectional study was conducted with ophthalmological evaluations of patients with HD from June 2017 to June 2018. Diagnostic ocular findings, corrected visual acuity, and refractive error were described. Findings were correlated with patients’ clinical and epidemiological variables. A total of 86 patients were evaluated, with a mean age of 50.1 years, predominantly males (59.3%), and with multibacillary HD (92%). The prevalence of ophthalmologic changes was 100% and the most common were dysfunction of the Meibomian glands (89.5%) and dry eye syndrome (81.4%). Cataracts were observed in 22 patients (25.6%), but best corrected visual acuity was normal or near normal in 84 patients (97.7%) and there were no cases of bilateral blindness. Patients with some degree of physical disability had more ophthalmological alterations, involving both the ocular adnexa (p = 0.03) and the ocular globe (p = 0.04). Ocular involvement is common in patients with Hansen’s disease, reinforcing the importance of ophthalmologic examination in the evaluation and follow-up of these patients.
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spelling pubmed-75054692020-09-30 Evaluation of ocular involvement in patients with Hansen’s disease Pavezzi, Priscila Daiane do Prado, Rodrigo Bueno Boin Filho, Plinio Ângelo Gon, Airton dos Santos Tuma, Bruna Fornazieri, Marco Aurelio Scalone, Fabiana de Mari Alves, Luciana Rigolin Mazoni Montero, Ricardo Hirayama Casella, Antonio Marcelo Barbante PLoS Negl Trop Dis Research Article Hansen’s disease (HD) belongs to the group of neglected diseases and can cause physical deformities and disabilities, in addition to leading to social discrimination. Ocular involvement in HD is estimated at 70–75% worldwide. About 10–50% suffer from severe ocular symptoms and loss of vision occurs in approximately 5% of cases. Ocular changes may persist or worsen even after patients are considered cured and it is necessary to better understand these conditions in order to determine the need for additional public policies. The objective of this study was to identify the prevalence of ocular involvement in patients with HD at two specialist referral centers for treatment of the disease. A cross-sectional study was conducted with ophthalmological evaluations of patients with HD from June 2017 to June 2018. Diagnostic ocular findings, corrected visual acuity, and refractive error were described. Findings were correlated with patients’ clinical and epidemiological variables. A total of 86 patients were evaluated, with a mean age of 50.1 years, predominantly males (59.3%), and with multibacillary HD (92%). The prevalence of ophthalmologic changes was 100% and the most common were dysfunction of the Meibomian glands (89.5%) and dry eye syndrome (81.4%). Cataracts were observed in 22 patients (25.6%), but best corrected visual acuity was normal or near normal in 84 patients (97.7%) and there were no cases of bilateral blindness. Patients with some degree of physical disability had more ophthalmological alterations, involving both the ocular adnexa (p = 0.03) and the ocular globe (p = 0.04). Ocular involvement is common in patients with Hansen’s disease, reinforcing the importance of ophthalmologic examination in the evaluation and follow-up of these patients. Public Library of Science 2020-09-21 /pmc/articles/PMC7505469/ /pubmed/32956360 http://dx.doi.org/10.1371/journal.pntd.0008585 Text en © 2020 Pavezzi et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Pavezzi, Priscila Daiane
do Prado, Rodrigo Bueno
Boin Filho, Plinio Ângelo
Gon, Airton dos Santos
Tuma, Bruna
Fornazieri, Marco Aurelio
Scalone, Fabiana de Mari
Alves, Luciana Rigolin Mazoni
Montero, Ricardo Hirayama
Casella, Antonio Marcelo Barbante
Evaluation of ocular involvement in patients with Hansen’s disease
title Evaluation of ocular involvement in patients with Hansen’s disease
title_full Evaluation of ocular involvement in patients with Hansen’s disease
title_fullStr Evaluation of ocular involvement in patients with Hansen’s disease
title_full_unstemmed Evaluation of ocular involvement in patients with Hansen’s disease
title_short Evaluation of ocular involvement in patients with Hansen’s disease
title_sort evaluation of ocular involvement in patients with hansen’s disease
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7505469/
https://www.ncbi.nlm.nih.gov/pubmed/32956360
http://dx.doi.org/10.1371/journal.pntd.0008585
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