Toll-like receptor 4-mediated inflammation triggered by extracellular IFI16 is enhanced by lipopolysaccharide binding

Damage-associated molecular patterns (DAMPs) are endogenous molecules activating the immune system upon release from injured cells. Here we show that the IFI16 protein, once freely released in the extracellular milieu of chronically inflamed tissues, can function as a DAMP either alone or upon bindi...

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Detalles Bibliográficos
Autores principales: Iannucci, Andrea, Caneparo, Valeria, Raviola, Stefano, Debernardi, Isacco, Colangelo, Donato, Miggiano, Riccardo, Griffante, Gloria, Landolfo, Santo, Gariglio, Marisa, De Andrea, Marco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7505474/
https://www.ncbi.nlm.nih.gov/pubmed/32903274
http://dx.doi.org/10.1371/journal.ppat.1008811

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