SARS-CoV-2 host receptors ACE2 and CD147 (BSG) are present on human oocytes and blastocysts

PURPOSE: To visualize SARS-CoV-2 host receptors ACE2 and CD147 on human oocytes and blastocysts. METHODS: Immunohistochemistry and confocal microscopy on human primary oocytes and pre (5 days post fertilization (dpf5) and (dpf6))- and peri (dpf7)-implantation blastocysts donated to research. RESULTS...

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Detalles Bibliográficos
Autores principales: Essahib, Wafaa, Verheyen, Greta, Tournaye, Herman, Van de Velde, Hilde
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2020
Materias:
Reproductive Physiology and Disease
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7505486/
https://www.ncbi.nlm.nih.gov/pubmed/32959144
http://dx.doi.org/10.1007/s10815-020-01952-x
Descripción
Sumario:PURPOSE: To visualize SARS-CoV-2 host receptors ACE2 and CD147 on human oocytes and blastocysts. METHODS: Immunohistochemistry and confocal microscopy on human primary oocytes and pre (5 days post fertilization (dpf5) and (dpf6))- and peri (dpf7)-implantation blastocysts donated to research. RESULTS: SARS-CoV-2 host receptors ACE2 and CD147 are present on the membrane of trophectoderm, epiblast and hypoblast cells in human blastocysts. CD147 is also present on the oolemma. CONCLUSION: Theoretically, the earliest stages of embryonic development may be vulnerable for SARS-CoV-2 infection.

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