SARS-CoV-2 host receptors ACE2 and CD147 (BSG) are present on human oocytes and blastocysts

PURPOSE: To visualize SARS-CoV-2 host receptors ACE2 and CD147 on human oocytes and blastocysts. METHODS: Immunohistochemistry and confocal microscopy on human primary oocytes and pre (5 days post fertilization (dpf5) and (dpf6))- and peri (dpf7)-implantation blastocysts donated to research. RESULTS...

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Detalles Bibliográficos
Autores principales: Essahib, Wafaa, Verheyen, Greta, Tournaye, Herman, Van de Velde, Hilde
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2020
Materias:
Reproductive Physiology and Disease
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7505486/
https://www.ncbi.nlm.nih.gov/pubmed/32959144
http://dx.doi.org/10.1007/s10815-020-01952-x
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author Essahib, Wafaa
Verheyen, Greta
Tournaye, Herman
Van de Velde, Hilde
author_facet Essahib, Wafaa
Verheyen, Greta
Tournaye, Herman
Van de Velde, Hilde
author_sort Essahib, Wafaa
collection PubMed
description PURPOSE: To visualize SARS-CoV-2 host receptors ACE2 and CD147 on human oocytes and blastocysts. METHODS: Immunohistochemistry and confocal microscopy on human primary oocytes and pre (5 days post fertilization (dpf5) and (dpf6))- and peri (dpf7)-implantation blastocysts donated to research. RESULTS: SARS-CoV-2 host receptors ACE2 and CD147 are present on the membrane of trophectoderm, epiblast and hypoblast cells in human blastocysts. CD147 is also present on the oolemma. CONCLUSION: Theoretically, the earliest stages of embryonic development may be vulnerable for SARS-CoV-2 infection.
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spelling pubmed-75054862020-09-23 SARS-CoV-2 host receptors ACE2 and CD147 (BSG) are present on human oocytes and blastocysts Essahib, Wafaa Verheyen, Greta Tournaye, Herman Van de Velde, Hilde J Assist Reprod Genet Reproductive Physiology and Disease PURPOSE: To visualize SARS-CoV-2 host receptors ACE2 and CD147 on human oocytes and blastocysts. METHODS: Immunohistochemistry and confocal microscopy on human primary oocytes and pre (5 days post fertilization (dpf5) and (dpf6))- and peri (dpf7)-implantation blastocysts donated to research. RESULTS: SARS-CoV-2 host receptors ACE2 and CD147 are present on the membrane of trophectoderm, epiblast and hypoblast cells in human blastocysts. CD147 is also present on the oolemma. CONCLUSION: Theoretically, the earliest stages of embryonic development may be vulnerable for SARS-CoV-2 infection. Springer US 2020-09-21 2020-11 /pmc/articles/PMC7505486/ /pubmed/32959144 http://dx.doi.org/10.1007/s10815-020-01952-x Text en © Springer Science+Business Media, LLC, part of Springer Nature 2020
spellingShingle Reproductive Physiology and Disease
Essahib, Wafaa
Verheyen, Greta
Tournaye, Herman
Van de Velde, Hilde
SARS-CoV-2 host receptors ACE2 and CD147 (BSG) are present on human oocytes and blastocysts
title SARS-CoV-2 host receptors ACE2 and CD147 (BSG) are present on human oocytes and blastocysts
title_full SARS-CoV-2 host receptors ACE2 and CD147 (BSG) are present on human oocytes and blastocysts
title_fullStr SARS-CoV-2 host receptors ACE2 and CD147 (BSG) are present on human oocytes and blastocysts
title_full_unstemmed SARS-CoV-2 host receptors ACE2 and CD147 (BSG) are present on human oocytes and blastocysts
title_short SARS-CoV-2 host receptors ACE2 and CD147 (BSG) are present on human oocytes and blastocysts
title_sort sars-cov-2 host receptors ace2 and cd147 (bsg) are present on human oocytes and blastocysts
topic Reproductive Physiology and Disease
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7505486/
https://www.ncbi.nlm.nih.gov/pubmed/32959144
http://dx.doi.org/10.1007/s10815-020-01952-x
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