Limited Added Value of Oropharyngeal Swabs for Detecting Pneumococcal Carriage in Adults

We compared pneumococcal isolation rates and evaluated the benefit of using oropharyngeal (OP) specimens in addition to nasopharyngeal (NP) specimens collected from adults in rural Kenya. Of 846 adults, 52.1% were colonized; pneumococci were detected from both NP and OP specimens in 23.5%, NP only i...

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Detalles Bibliográficos
Autores principales: Farrar, Jennifer L, Odiembo, Herine, Odoyo, Arthur, Bigogo, Godfrey, Kim, Lindsay, Lessa, Fernanda C, Feikin, Daniel R, Breiman, Robert F, Whitney, Cynthia G, Carvalho, Maria G, Pimenta, Fabiana C
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Brief Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7505525/
https://www.ncbi.nlm.nih.gov/pubmed/32995349
http://dx.doi.org/10.1093/ofid/ofaa368
Descripción
Sumario:We compared pneumococcal isolation rates and evaluated the benefit of using oropharyngeal (OP) specimens in addition to nasopharyngeal (NP) specimens collected from adults in rural Kenya. Of 846 adults, 52.1% were colonized; pneumococci were detected from both NP and OP specimens in 23.5%, NP only in 22.9%, and OP only in 5.7%. Ten-valent pneumococcal conjugate vaccine strains were detected from both NP and OP in 3.4%, NP only in 4.1%, and OP only in 0.7%. Inclusion of OP swabs increased carriage detection by 5.7%; however, the added cost of collecting and processing OP specimens may justify exclusion from future carriage studies among adults.

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