Limited Added Value of Oropharyngeal Swabs for Detecting Pneumococcal Carriage in Adults

We compared pneumococcal isolation rates and evaluated the benefit of using oropharyngeal (OP) specimens in addition to nasopharyngeal (NP) specimens collected from adults in rural Kenya. Of 846 adults, 52.1% were colonized; pneumococci were detected from both NP and OP specimens in 23.5%, NP only i...

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Autores principales: Farrar, Jennifer L, Odiembo, Herine, Odoyo, Arthur, Bigogo, Godfrey, Kim, Lindsay, Lessa, Fernanda C, Feikin, Daniel R, Breiman, Robert F, Whitney, Cynthia G, Carvalho, Maria G, Pimenta, Fabiana C
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Brief Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7505525/
https://www.ncbi.nlm.nih.gov/pubmed/32995349
http://dx.doi.org/10.1093/ofid/ofaa368
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author Farrar, Jennifer L
Odiembo, Herine
Odoyo, Arthur
Bigogo, Godfrey
Kim, Lindsay
Lessa, Fernanda C
Feikin, Daniel R
Breiman, Robert F
Whitney, Cynthia G
Carvalho, Maria G
Pimenta, Fabiana C
author_facet Farrar, Jennifer L
Odiembo, Herine
Odoyo, Arthur
Bigogo, Godfrey
Kim, Lindsay
Lessa, Fernanda C
Feikin, Daniel R
Breiman, Robert F
Whitney, Cynthia G
Carvalho, Maria G
Pimenta, Fabiana C
author_sort Farrar, Jennifer L
collection PubMed
description We compared pneumococcal isolation rates and evaluated the benefit of using oropharyngeal (OP) specimens in addition to nasopharyngeal (NP) specimens collected from adults in rural Kenya. Of 846 adults, 52.1% were colonized; pneumococci were detected from both NP and OP specimens in 23.5%, NP only in 22.9%, and OP only in 5.7%. Ten-valent pneumococcal conjugate vaccine strains were detected from both NP and OP in 3.4%, NP only in 4.1%, and OP only in 0.7%. Inclusion of OP swabs increased carriage detection by 5.7%; however, the added cost of collecting and processing OP specimens may justify exclusion from future carriage studies among adults.
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spelling pubmed-75055252020-09-28 Limited Added Value of Oropharyngeal Swabs for Detecting Pneumococcal Carriage in Adults Farrar, Jennifer L Odiembo, Herine Odoyo, Arthur Bigogo, Godfrey Kim, Lindsay Lessa, Fernanda C Feikin, Daniel R Breiman, Robert F Whitney, Cynthia G Carvalho, Maria G Pimenta, Fabiana C Open Forum Infect Dis Brief Reports We compared pneumococcal isolation rates and evaluated the benefit of using oropharyngeal (OP) specimens in addition to nasopharyngeal (NP) specimens collected from adults in rural Kenya. Of 846 adults, 52.1% were colonized; pneumococci were detected from both NP and OP specimens in 23.5%, NP only in 22.9%, and OP only in 5.7%. Ten-valent pneumococcal conjugate vaccine strains were detected from both NP and OP in 3.4%, NP only in 4.1%, and OP only in 0.7%. Inclusion of OP swabs increased carriage detection by 5.7%; however, the added cost of collecting and processing OP specimens may justify exclusion from future carriage studies among adults. Oxford University Press 2020-08-18 /pmc/articles/PMC7505525/ /pubmed/32995349 http://dx.doi.org/10.1093/ofid/ofaa368 Text en © The Author(s) 2020. Published by Oxford University Press on behalf of Infectious Diseases Society of America. http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Brief Reports
Farrar, Jennifer L
Odiembo, Herine
Odoyo, Arthur
Bigogo, Godfrey
Kim, Lindsay
Lessa, Fernanda C
Feikin, Daniel R
Breiman, Robert F
Whitney, Cynthia G
Carvalho, Maria G
Pimenta, Fabiana C
Limited Added Value of Oropharyngeal Swabs for Detecting Pneumococcal Carriage in Adults
title Limited Added Value of Oropharyngeal Swabs for Detecting Pneumococcal Carriage in Adults
title_full Limited Added Value of Oropharyngeal Swabs for Detecting Pneumococcal Carriage in Adults
title_fullStr Limited Added Value of Oropharyngeal Swabs for Detecting Pneumococcal Carriage in Adults
title_full_unstemmed Limited Added Value of Oropharyngeal Swabs for Detecting Pneumococcal Carriage in Adults
title_short Limited Added Value of Oropharyngeal Swabs for Detecting Pneumococcal Carriage in Adults
title_sort limited added value of oropharyngeal swabs for detecting pneumococcal carriage in adults
topic Brief Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7505525/
https://www.ncbi.nlm.nih.gov/pubmed/32995349
http://dx.doi.org/10.1093/ofid/ofaa368
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