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Dynamic brain-body coupling of breath-by-breath O(2)-CO(2) exchange ratio with resting state cerebral hemodynamic fluctuations

BACKGROUND: The origin of low frequency cerebral hemodynamic fluctuations (CHF) in the resting state remains unknown. Breath-by breath O(2)-CO(2) exchange ratio (bER) has been reported to correlate with the cerebrovascular response to brief breath hold challenge at the frequency range of 0.008–0.03H...

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Autores principales: Chan, Suk-tak, Evans, Karleyton C., Song, Tian-yue, Selb, Juliette, van der Kouwe, Andre, Rosen, Bruce R., Zheng, Yong-ping, Ahn, Andrew C., Kwong, Kenneth K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7505589/
https://www.ncbi.nlm.nih.gov/pubmed/32956397
http://dx.doi.org/10.1371/journal.pone.0238946
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author Chan, Suk-tak
Evans, Karleyton C.
Song, Tian-yue
Selb, Juliette
van der Kouwe, Andre
Rosen, Bruce R.
Zheng, Yong-ping
Ahn, Andrew C.
Kwong, Kenneth K.
author_facet Chan, Suk-tak
Evans, Karleyton C.
Song, Tian-yue
Selb, Juliette
van der Kouwe, Andre
Rosen, Bruce R.
Zheng, Yong-ping
Ahn, Andrew C.
Kwong, Kenneth K.
author_sort Chan, Suk-tak
collection PubMed
description BACKGROUND: The origin of low frequency cerebral hemodynamic fluctuations (CHF) in the resting state remains unknown. Breath-by breath O(2)-CO(2) exchange ratio (bER) has been reported to correlate with the cerebrovascular response to brief breath hold challenge at the frequency range of 0.008–0.03Hz in healthy adults. bER is defined as the ratio of the change in the partial pressure of oxygen (ΔPO(2)) to that of carbon dioxide (ΔPCO(2)) between end inspiration and end expiration. In this study, we aimed to investigate the contribution of respiratory gas exchange (RGE) metrics (bER, ΔPO(2) and ΔPCO(2)) to low frequency CHF during spontaneous breathing. METHODS: Twenty-two healthy adults were included. We used transcranial Doppler sonography to evaluate CHF by measuring the changes in cerebral blood flow velocity (ΔCBFv) in bilateral middle cerebral arteries. The regional CHF were mapped with blood oxygenation level dependent (ΔBOLD) signal changes using functional magnetic resonance imaging. Temporal features and frequency characteristics of RGE metrics during spontaneous breathing were examined, and the simultaneous measurements of RGE metrics and CHF (ΔCBFv and ΔBOLD) were studied for their correlation. RESULTS: We found that the time courses of ΔPO(2) and ΔPCO(2) were interdependent but not redundant. The oscillations of RGE metrics were coherent with resting state CHF at the frequency range of 0.008–0.03Hz. Both bER and ΔPO(2) were superior to ΔPCO(2) in association with CHF while CHF could correlate more strongly with bER than with ΔPO(2) in some brain regions. Brain regions with the strongest coupling between bER and ΔBOLD overlapped with many areas of default mode network including precuneus and posterior cingulate. CONCLUSION: Although the physiological mechanisms underlying the strong correlation between bER and CHF are unclear, our findings suggest the contribution of bER to low frequency resting state CHF, providing a novel insight of brain-body interaction via CHF and oscillations of RGE metrics.
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spelling pubmed-75055892020-09-30 Dynamic brain-body coupling of breath-by-breath O(2)-CO(2) exchange ratio with resting state cerebral hemodynamic fluctuations Chan, Suk-tak Evans, Karleyton C. Song, Tian-yue Selb, Juliette van der Kouwe, Andre Rosen, Bruce R. Zheng, Yong-ping Ahn, Andrew C. Kwong, Kenneth K. PLoS One Research Article BACKGROUND: The origin of low frequency cerebral hemodynamic fluctuations (CHF) in the resting state remains unknown. Breath-by breath O(2)-CO(2) exchange ratio (bER) has been reported to correlate with the cerebrovascular response to brief breath hold challenge at the frequency range of 0.008–0.03Hz in healthy adults. bER is defined as the ratio of the change in the partial pressure of oxygen (ΔPO(2)) to that of carbon dioxide (ΔPCO(2)) between end inspiration and end expiration. In this study, we aimed to investigate the contribution of respiratory gas exchange (RGE) metrics (bER, ΔPO(2) and ΔPCO(2)) to low frequency CHF during spontaneous breathing. METHODS: Twenty-two healthy adults were included. We used transcranial Doppler sonography to evaluate CHF by measuring the changes in cerebral blood flow velocity (ΔCBFv) in bilateral middle cerebral arteries. The regional CHF were mapped with blood oxygenation level dependent (ΔBOLD) signal changes using functional magnetic resonance imaging. Temporal features and frequency characteristics of RGE metrics during spontaneous breathing were examined, and the simultaneous measurements of RGE metrics and CHF (ΔCBFv and ΔBOLD) were studied for their correlation. RESULTS: We found that the time courses of ΔPO(2) and ΔPCO(2) were interdependent but not redundant. The oscillations of RGE metrics were coherent with resting state CHF at the frequency range of 0.008–0.03Hz. Both bER and ΔPO(2) were superior to ΔPCO(2) in association with CHF while CHF could correlate more strongly with bER than with ΔPO(2) in some brain regions. Brain regions with the strongest coupling between bER and ΔBOLD overlapped with many areas of default mode network including precuneus and posterior cingulate. CONCLUSION: Although the physiological mechanisms underlying the strong correlation between bER and CHF are unclear, our findings suggest the contribution of bER to low frequency resting state CHF, providing a novel insight of brain-body interaction via CHF and oscillations of RGE metrics. Public Library of Science 2020-09-21 /pmc/articles/PMC7505589/ /pubmed/32956397 http://dx.doi.org/10.1371/journal.pone.0238946 Text en © 2020 Chan et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Chan, Suk-tak
Evans, Karleyton C.
Song, Tian-yue
Selb, Juliette
van der Kouwe, Andre
Rosen, Bruce R.
Zheng, Yong-ping
Ahn, Andrew C.
Kwong, Kenneth K.
Dynamic brain-body coupling of breath-by-breath O(2)-CO(2) exchange ratio with resting state cerebral hemodynamic fluctuations
title Dynamic brain-body coupling of breath-by-breath O(2)-CO(2) exchange ratio with resting state cerebral hemodynamic fluctuations
title_full Dynamic brain-body coupling of breath-by-breath O(2)-CO(2) exchange ratio with resting state cerebral hemodynamic fluctuations
title_fullStr Dynamic brain-body coupling of breath-by-breath O(2)-CO(2) exchange ratio with resting state cerebral hemodynamic fluctuations
title_full_unstemmed Dynamic brain-body coupling of breath-by-breath O(2)-CO(2) exchange ratio with resting state cerebral hemodynamic fluctuations
title_short Dynamic brain-body coupling of breath-by-breath O(2)-CO(2) exchange ratio with resting state cerebral hemodynamic fluctuations
title_sort dynamic brain-body coupling of breath-by-breath o(2)-co(2) exchange ratio with resting state cerebral hemodynamic fluctuations
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7505589/
https://www.ncbi.nlm.nih.gov/pubmed/32956397
http://dx.doi.org/10.1371/journal.pone.0238946
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