Cefepime Neurotoxicity in a Patient With Acute Tubular Necrosis

Neurotoxicity is a rare side effect of Cefepime use. Cefepime can cross the blood-brain barrier and can be neurotoxic by competitive albeit weak antagonism of the gamma-aminobutyric acid complex. It is cleared by the kidneys which puts individuals with renal impairment at risk of side effects. We de...

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Detalles Bibliográficos
Autores principales: Ojha, Niranjan, Riaz, Sana, Eranki, Ambika
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2020
Materias:
Internal Medicine
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7505636/
https://www.ncbi.nlm.nih.gov/pubmed/32968574
http://dx.doi.org/10.7759/cureus.9911
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author Ojha, Niranjan
Riaz, Sana
Eranki, Ambika
author_facet Ojha, Niranjan
Riaz, Sana
Eranki, Ambika
author_sort Ojha, Niranjan
collection PubMed
description Neurotoxicity is a rare side effect of Cefepime use. Cefepime can cross the blood-brain barrier and can be neurotoxic by competitive albeit weak antagonism of the gamma-aminobutyric acid complex. It is cleared by the kidneys which puts individuals with renal impairment at risk of side effects. We describe a case of Cefepime neurotoxicity in the context of nephrotoxicity secondary to the use of other drugs.
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spelling pubmed-75056362020-09-22 Cefepime Neurotoxicity in a Patient With Acute Tubular Necrosis Ojha, Niranjan Riaz, Sana Eranki, Ambika Cureus Internal Medicine Neurotoxicity is a rare side effect of Cefepime use. Cefepime can cross the blood-brain barrier and can be neurotoxic by competitive albeit weak antagonism of the gamma-aminobutyric acid complex. It is cleared by the kidneys which puts individuals with renal impairment at risk of side effects. We describe a case of Cefepime neurotoxicity in the context of nephrotoxicity secondary to the use of other drugs. Cureus 2020-08-21 /pmc/articles/PMC7505636/ /pubmed/32968574 http://dx.doi.org/10.7759/cureus.9911 Text en Copyright © 2020, Ojha et al. http://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Internal Medicine
Ojha, Niranjan
Riaz, Sana
Eranki, Ambika
Cefepime Neurotoxicity in a Patient With Acute Tubular Necrosis
title Cefepime Neurotoxicity in a Patient With Acute Tubular Necrosis
title_full Cefepime Neurotoxicity in a Patient With Acute Tubular Necrosis
title_fullStr Cefepime Neurotoxicity in a Patient With Acute Tubular Necrosis
title_full_unstemmed Cefepime Neurotoxicity in a Patient With Acute Tubular Necrosis
title_short Cefepime Neurotoxicity in a Patient With Acute Tubular Necrosis
title_sort cefepime neurotoxicity in a patient with acute tubular necrosis
topic Internal Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7505636/
https://www.ncbi.nlm.nih.gov/pubmed/32968574
http://dx.doi.org/10.7759/cureus.9911
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AT riazsana cefepimeneurotoxicityinapatientwithacutetubularnecrosis
AT erankiambika cefepimeneurotoxicityinapatientwithacutetubularnecrosis

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